[HTML][HTML] Personalized cancer vaccines: clinical landscape, challenges, and opportunities

CS Shemesh, JC Hsu, I Hosseini, BQ Shen, A Rotte… - Molecular Therapy, 2021 - cell.com
Tremendous innovation is underway among a rapidly expanding repertoire of promising
personalized immune-based treatments. Therapeutic cancer vaccines (TCVs) are attractive …

Role of tumor-infiltrating lymphocytes in patients with solid tumors: Can a drop dig a stone?

G Badalamenti, D Fanale, L Incorvaia, N Barraco… - Cellular …, 2019 - Elsevier
In recent years, multiple strategies for eliciting anti-tumor immunity have been developed in
different clinical studies. Currently, immunotherapy was clinically validated as effective …

Review of functionalized nanomaterials for photothermal therapy of cancers

W Bian, Y Wang, Z Pan, N Chen, X Li… - ACS Applied Nano …, 2021 - ACS Publications
Photothermal therapy (PTT) is recognized as a promising approach for cancer theranostics
via the nonradiative conversion of light into heat energy. PTT treatment is able to reduce the …

In Situ Tumor PD-L1 mRNA Expression Is Associated with Increased TILs and Better Outcome in Breast Carcinomas

KA Schalper, V Velcheti, D Carvajal, H Wimberly… - Clinical cancer …, 2014 - AACR
Purpose: Blockade of the PD-1/PD-L1 axis emerged as a promising new therapeutic option
for cancer that has resulted in lasting responses in metastatic renal, lung carcinomas, and …

Tumor subtype-specific cancer–testis antigens as potential biomarkers and immunotherapeutic targets for cancers

J Yao, OL Caballero, WKA Yung, JN Weinstein… - Cancer immunology …, 2014 - AACR
Cancer–testis (CT) antigens are potential targets for cancer immunotherapy because of their
restricted expression in immune-privileged germ cells and various malignancies. Current …

Tumor-infiltrating lymphocytes in triple negative breast cancer: the future of immune targeting

P García-Teijido, ML Cabal… - Clinical Medicine …, 2016 - journals.sagepub.com
Triple negative breast cancer (TNBC) is a highly heterogeneous tumor. There is increasing
evidence of the role of tumor lymphocytic immune infiltrates in this subtype of breast cancer …

Reprogramming metastatic tumour cells with embryonic microenvironments

MJC Hendrix, EA Seftor, REB Seftor… - Nature Reviews …, 2007 - nature.com
Aggressive tumour cells share many characteristics with embryonic progenitors, contributing
to the conundrum of tumour cell plasticity. Recent studies using embryonic models of human …

Tumor-driven evolution of immunosuppressive networks during malignant progression

R Kim, M Emi, K Tanabe, K Arihiro - Cancer research, 2006 - AACR
Tumors evolve mechanisms to escape immune control by a process called immune editing,
which provides a selective pressure in the tumor microenvironment that could lead to …

Serum autoantibodies as biomarkers for early cancer detection

HT Tan, J Low, SG Lim, MCM Chung - The FEBS journal, 2009 - Wiley Online Library
Autoantibodies against autologus tumor‐associated antigens have been detected in the
asymptomatic stage of cancer and can thus serve as biomarkers for early cancer diagnosis …

Chemokines: agents for the immunotherapy of cancer?

B Homey, A Müller, A Zlotnik - Nature Reviews Immunology, 2002 - nature.com
Chemokines, a superfamilly of small cytokine-like molecules, regulate leukocyte transport in
the body. In recent years, we have witnessed the transition of immunotherapeutic strategies …