[HTML][HTML] Receptor tyrosine kinases in osteosarcoma treatment: which is the key target?
Z Tian, X Niu, W Yao - Frontiers in Oncology, 2020 - frontiersin.org
Recent clinical trials have shown several multi-target tyrosine kinase inhibitors (TKIs) to be
effective in the treatment of osteosarcoma. However, these TKIs have a number of targets …
effective in the treatment of osteosarcoma. However, these TKIs have a number of targets …
[HTML][HTML] Lung-specific MCEMP1 functions as an adaptor for KIT to promote SCF-mediated mast cell proliferation
Lung mast cells are important in host defense, and excessive proliferation or activation of
these cells can cause chronic inflammatory disorders like asthma. Two parallel pathways …
these cells can cause chronic inflammatory disorders like asthma. Two parallel pathways …
KIT as a master regulator of the mast cell lineage
The discovery in 1987/1988 and 1990 of the cell surface receptor KIT and its ligand, stem
cell factor (SCF), was a critical achievement in efforts to understand the development and …
cell factor (SCF), was a critical achievement in efforts to understand the development and …
[HTML][HTML] Organoid-derived C-Kit+/SSEA4− human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents
T Zou, L Gao, Y Zeng, Q Li, Y Li, S Chen, X Hu… - Nature …, 2019 - nature.com
Stem cell therapy may replace lost photoreceptors and preserve residual photoreceptors
during retinal degeneration (RD). Unfortunately, the degenerative microenvironment …
during retinal degeneration (RD). Unfortunately, the degenerative microenvironment …
Small molecule inhibitors targeting the cancers
Compared with traditional therapies, targeted therapy has merits in selectivity, efficacy, and
tolerability. Small molecule inhibitors are one of the primary targeted therapies for cancer …
tolerability. Small molecule inhibitors are one of the primary targeted therapies for cancer …
In Vivo RNA Delivery to Hematopoietic Stem and Progenitor Cells via Targeted Lipid Nanoparticles
D Shi, S Toyonaga, DG Anderson - Nano Letters, 2023 - ACS Publications
Ex vivo autologous hematopoietic stem cell (HSC) gene therapy has provided new therapies
for the treatment of hematological disorders. However, these therapies have several …
for the treatment of hematological disorders. However, these therapies have several …
[HTML][HTML] Enhancing endogenous capacity to repair a stroke-damaged brain: An evolving field for stroke research
LR Zhao, A Willing - Progress in neurobiology, 2018 - Elsevier
Stroke represents a severe medical condition that causes stroke survivors to suffer from long-
term and even lifelong disability. Over the past several decades, a vast majority of stroke …
term and even lifelong disability. Over the past several decades, a vast majority of stroke …
The hallmarks of ovarian cancer stem cells and niches: Exploring their harmonious interplay in therapy resistance
T Motohara, GJ Yoshida, H Katabuchi - Seminars in Cancer Biology, 2021 - Elsevier
The concept of a “cancer stem cell” has evolved over the past decades, and research on
cancer stem cell biology has entered into a stage of remarkable progress. Cancer stem cells …
cancer stem cell biology has entered into a stage of remarkable progress. Cancer stem cells …
Anti-human CD117 CAR T-cells efficiently eliminate healthy and malignant CD117-expressing hematopoietic cells
Acute myeloid leukemia (AML) initiating and sustaining cells maintain high cell-surface
similarity with their cells-of-origin, ie, hematopoietic stem and progenitor cells (HSPCs), and …
similarity with their cells-of-origin, ie, hematopoietic stem and progenitor cells (HSPCs), and …
Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention
SG Krimmer, N Bertoletti, Y Suzuki… - Proceedings of the …, 2023 - National Acad Sciences
The receptor tyrosine kinase KIT and its ligand stem cell factor (SCF) are required for the
development of hematopoietic stem cells, germ cells, and other cells. A variety of human …
development of hematopoietic stem cells, germ cells, and other cells. A variety of human …