In mammals, females are born with finite numbers of oocytes stockpiled as primordial
follicles. Oocytes are “reawakened” via an ovarian-intrinsic process that initiates their …

The proto-oncogene KIT encodes for a tyrosine kinase receptor, which is a clinically
validated target for treating gastrointestinal stromal tumors. The KIT promoter contains a G …

There is evidence demonstrating that heart failure (HF) occurs in 1–2% of the global
population and is often accompanied by comorbidities which contribute to increasing the …

Experimental organometallic gold (I) compounds hold promise for anticancer therapy. This
study reports the synthesis of two novel families of gold (I) complexes, including N1 …

Membrane-bound factors expressed by niche stromal cells constitute a unique class of
localized cues and regulate the long-term functions of adult stem cells, yet little is known …

Bone marrow mesenchymal stromal cells are a highly heterogenic cell population
containing mesenchymal stem cells as well as other cell types. With the advance of single …

Background Recently, progress has been made in the development of targeted therapies for
human epidermal growth factor receptor 2 (HER2)-positive gastric cancer (GC). However …

Thymic T cell development is initiated from bone-marrow-derived multi potent thymus-
seeding progenitors. During the early stages of thymocyte differentiation, progenitors …

The noncanonical guanine-rich DNAs have drawn particular attention to the scientific world
due to their controllable diverse and polymorphic structures. Apart from biological and …

Anaphylaxis is an acute, potentially life-threatening systemic allergic reaction for which there
are no known reliable preventative therapies. Its primary cell mediator, the mast cell, has …