Group 3 innate lymphoid cells accumulate and exhibit disease-induced activation in the meninges in EAE
JK Hatfield, MA Brown - Cellular immunology, 2015 - Elsevier
Innate lymphoid cells are immune cells that reside in tissues that interface with the external
environment and contribute to the first line defense against pathogens. However, they also …
environment and contribute to the first line defense against pathogens. However, they also …
[HTML][HTML] Pharmacology and rationale for seralutinib in the treatment of pulmonary arterial hypertension
SS Pullamsetti, R Sitapara, R Osterhout… - International Journal of …, 2023 - mdpi.com
Pulmonary arterial hypertension (PAH) is a complex disorder characterized by vascular
remodeling and a consequent increase in pulmonary vascular resistance. The histologic …
remodeling and a consequent increase in pulmonary vascular resistance. The histologic …
Identification of M4205─ A highly selective inhibitor of KIT mutations for treatment of unresectable metastatic or recurrent gastrointestinal stromal tumors
A Blum, D Dorsch, N Linde, S Brandstetter… - Journal of Medicinal …, 2023 - ACS Publications
The treatment of gastrointestinal stromal tumors (GISTs) driven by activating mutations in the
KIT gene is a prime example of targeted therapy for treatment of cancer. The approval of the …
KIT gene is a prime example of targeted therapy for treatment of cancer. The approval of the …
[HTML][HTML] Targeting stress erythropoiesis pathways in cancer
S Vignjević Petrinović, A Jauković, M Milošević… - Frontiers in …, 2022 - frontiersin.org
Cancer-related anemia (CRA) is a common multifactorial disorder that adversely affects the
quality of life and overall prognosis in patients with cancer. Safety concerns associated with …
quality of life and overall prognosis in patients with cancer. Safety concerns associated with …
Preclinical antitumor activity of a novel anti–c-KIT antibody–drug conjugate against mutant and wild-type c-KIT–positive solid tumors
T Abrams, A Connor, C Fanton, SB Cohen… - Clinical Cancer …, 2018 - AACR
Purpose: c-KIT overexpression is well recognized in cancers such as gastrointestinal
stromal tumors (GIST), small cell lung cancer (SCLC), melanoma, non–small cell lung …
stromal tumors (GIST), small cell lung cancer (SCLC), melanoma, non–small cell lung …
Signaling circuits in early B-cell development
M Reth, P Nielsen - Advances in immunology, 2014 - Elsevier
Early B-cell development is an ordered and highly regulated process with alternating
phases of cell proliferation and differentiation leading to B cells with the ability to recognize …
phases of cell proliferation and differentiation leading to B cells with the ability to recognize …
[HTML][HTML] CREB Is Activated by the SCF/KIT Axis in a Partially ERK-Dependent Manner and Orchestrates Survival and the Induction of Immediate Early Genes in …
K Franke, G Bal, Z Li, T Zuberbier… - International Journal of …, 2023 - mdpi.com
cAMP response element binding protein (CREB) functions as a prototypical stimulus-
inducible transcription factor (TF) that initiates multiple cellular changes in response to …
inducible transcription factor (TF) that initiates multiple cellular changes in response to …
Interplay of Three G-Quadruplex Units in the KIT Promoter
The proto-oncogene KIT encodes for a tyrosine kinase receptor, which is a clinically
validated target for treating gastrointestinal stromal tumors. The KIT promoter contains a G …
validated target for treating gastrointestinal stromal tumors. The KIT promoter contains a G …
[HTML][HTML] c-kit Haploinsufficiency impairs adult cardiac stem cell growth, myogenicity and myocardial regeneration
I Aquila, E Cianflone, M Scalise, F Marino… - Cell death & …, 2019 - nature.com
An overdose of Isoproterenol (ISO) causes acute cardiomyocyte (CM) dropout and activates
the resident cardiac c-kitpos stem/progenitor cells (CSCs) generating a burst of new CM …
the resident cardiac c-kitpos stem/progenitor cells (CSCs) generating a burst of new CM …
The aryl hydrocarbon receptor: a review of its role in the physiology and pathology of the integument and its relationship to the tryptophan metabolism
R Noakes - International Journal of Tryptophan Research, 2015 - journals.sagepub.com
The aryl hydrocarbon receptor (AHR) is a cytosolic receptor for low molecular weight
molecules, of which the most widely recognized ligand is 2, 3, 7, 8-tetrachlorodibenzo-p …
molecules, of which the most widely recognized ligand is 2, 3, 7, 8-tetrachlorodibenzo-p …