Amorphous solid dispersions (ASDs) are a proven system for achieving a supersaturated
state of drug, in which the concentration of drug is greater than its crystalline solubility. The …

This review focuses on the self-aggregation properties of different drugs, as well as on their
interaction with anionic, cationic, and gemini surfactants. The interaction of drugs with …

This study aimed to develop microspheres using water-soluble carriers and surfactants to
improve the solubility, dissolution, and oral bioavailability of rivaroxaban (RXB). RXB-loaded …

In pharmaceutical technology, lipids and polymers are considered pillar excipients for the
fabrication of most dosage forms, irrespective of the administration route. They play various …

This article discusses the interaction of surfactants such as tetradecyltrimethylammonium
bromide (TTAB), hexadecyltrimethylammonium bromide (CTAB), cetylpyridinium chloride …

Amorphous solid dispersion (ASD) is a promising strategy to enhance solubility and
bioavailability of poorly water-soluble drugs. Due to higher free energy of ASD …

Abstract α-Tocopheryl polyethylene glycol succinate (vitamin E-TPGS or TPGS) is a nonionic
amphiphile synthesized by the esterification of vitamin E succinate. It has been categorized …

Polymeric amorphous solid dispersion (ASD) is a popular approach for enhancing the
solubility of poorly water-soluble drugs. However, achieving both physical stability and …

Understanding the dissolution mechanisms of amorphous solid dispersions (ASDs) and
being able to link enhanced drug exposure with process parameters are key when …

The formulation of oral amorphous solid dispersions (ASD) includes the use of excipients to
improve physical stability and enhance bioavailability. Combinations of excipients (polymers …