Polyphenols as potential metabolism mechanisms regulators in liver protection and liver cancer prevention

S Li, S Yin, H Ding, Y Shao, S Zhou, W Pu… - Cell …, 2023 - Wiley Online Library
Background Liver cancer is one of the common malignancies. The dysregulation of
metabolism is a driver of accelerated tumourigenesis. Metabolic changes are well …

Identification and management of acute alcohol intoxication

A Mirijello, L Sestito, M Antonelli, A Gasbarrini… - European journal of …, 2023 - Elsevier
Acute alcohol intoxication (AAI) is a harmful clinical condition, potentially life-threatening,
secondary to the intake of large amounts of alcohol. Clinical manifestations of AAI are …

Dihydromyricetin reverses thioacetamide-induced liver fibrosis through inhibiting NF-κB-mediated inflammation and TGF-β1-regulated of PI3K/Akt signaling pathway

Y Zhao, X Liu, C Ding, Y Gu, W Liu - Frontiers in pharmacology, 2021 - frontiersin.org
As a natural active substance, dihydromyricetin (DHM) has been proven to have good
hepatoprotective activity. However, the therapeutic effect of DHM on liver fibrosis, which has …

[HTML][HTML] Molecular mechanisms and therapeutic implications of dihydromyricetin in liver disease

J Chen, X Wang, T Xia, Y Bi, B Liu, J Fu… - Biomedicine & …, 2021 - Elsevier
Recent studies demonstrated that dihydromyricetin (DHM) has prominent therapeutic effects
on liver injury and liver cancer. By summarizing the current preclinical in vitro and in vivo …

Dihydromyricetin attenuates D-galactose-induced brain aging of mice via inhibiting oxidative stress and neuroinflammation

J Qian, X Wang, J Cao, W Zhang, C Lu, X Chen - Neuroscience Letters, 2021 - Elsevier
Aging-related especially brain aging-related diseases are heavy health care burdens
worldwide. Natural products with antioxidant and anti-inflammatory properties have been …

Natural compounds: a potential treatment for alcoholic liver disease?

J Yan, Y Nie, M Luo, Z Chen, B He - Frontiers in pharmacology, 2021 - frontiersin.org
Excessive alcohol intake is a direct cause of alcoholic liver disease (ALD). ALD usually
manifests as fatty liver in the initial stage and then develops into alcoholic hepatitis (ASH) …

Dihydromyricetin improves mitochondrial outcomes in the liver of alcohol-fed mice via the AMPK/Sirt-1/PGC-1α signaling axis

J Silva, MH Spatz, C Folk, A Chang, E Cadenas… - Alcohol, 2021 - Elsevier
Alcoholic liver disease (ALD), due to the multifactorial damage associated with alcohol
(ethanol) consumption and metabolism, is one of the most prevalent liver diseases in the …

Dihydromyricetin ameliorates liver fibrosis via inhibition of hepatic stellate cells by inducing autophagy and natural killer cell-mediated killing effect

X Zhou, L Yu, M Zhou, P Hou, L Yi, M Mi - Nutrition & Metabolism, 2021 - Springer
Background This study investigated the mechanisms underlying the preventive effect of
dihydromyricetin (DHM) against liver fibrosis involving hepatic stellate cells (HSCs) and …

[HTML][HTML] Recent update on application of dihydromyricetin in metabolic related diseases

Y Wang, J Wang, H Xiang, P Ding, T Wu, G Ji - Biomedicine & …, 2022 - Elsevier
As a new type of natural flavonoids, dihydromyricetin (DMY) has attracted more and more
attention. It has a series of pharmacological effects, such as anti-inflammatory, anti-tumor …

The role of alcohol metabolism in the pathology of alcohol hangover

M Mackus, AJAE Loo, J Garssen, AD Kraneveld… - Journal of Clinical …, 2020 - mdpi.com
The limited number of available studies that examined the pathology of alcohol hangover
focused on biomarkers of alcohol metabolism, oxidative stress and the inflammatory …