The double-stranded RNA-dependent protein kinase PKR is a critical mediator of the
antiproliferative and antiviral effects exerted by interferons. Not only is PKR an effector …

Considerable progress has been made in the understanding of the molecular biology of the
human interferon system. The genes encoding the interferons, their receptors, and the …

There is ample evidence that cells of higher eukaryotes express double-stranded RNA
molecules (dsRNAs) either naturally or as the result of viral infection or aberrant …

eIF-2a. One of these, the heme-controlled repressor (HCR), is chiefly (if not exclusively)
found in reticulocytes. This enzyme is activated by the absence of heme and by a number of …

Although inhibition of RNA interference (RNAi) by plant virus proteins has been shown to
enhance viral replication and pathogenesis in plants, no viral gene product has as yet been …

The interferon (IFN)-induced cellular antiviral response is the first line of defense against
viral infection within an animal host. In order to establish a productive infection, eukaryotic …

We show that human adenovirus inhibits RNA interference (RNAi) at late times of infection
by suppressing the activity of two key enzyme systems involved, Dicer and RNA-induced …

Phosphorylation of the alpha subunit of the eucaryotic translation initiation factor (eIF-2α) by
the double-stranded RNA-activated inhibitor (DAI) kinase correlates with inhibition of …

The interferon-inducible protein kinase PKR interacts with a number of small viral RNA
species, including adenovirus VA, RNA and the Epstein-Barr virusencoded RNA EBER-1 …

While many clinical hepatitis C virus (HCV) infections are resistant to alpha interferon (IFN-α)
therapy, subgenomic in vitro self-replicating HCV RNAs (HCV replicons) are characterized …