Ischemic stroke, accounting for 87% of stroke cases globally is a considerable source of
morbidity and mortality. After the initial thromboembolism of a cerebral vessel, secondary …

Biochemical pathways involved in maintaining the functions of various ocular structures are
very unique in nature. Therefore, understanding ocular biochemistry is of immense …

AQP0 water channels are the most abundant proteins expressed in the mammalian lens
fiber membranes where they are essential for lens development and transparency. Unlike …

In mice, the contraction of the ciliary muscle via the administration of pilocarpine reduces the
zonular tension applied to the lens and activates the TRPV1-mediated arm of a dual …

How neural circuits form and function has been an area of scientific research for over a
century. In my doctoral thesis, I aim to add to our understanding of these processes at a …

The ocular lens is responsible for focusing of light onto the retina and must maintain
transparency to effectively transmit light. Age related nuclear cataract is the most common …

Abstract Aquaporin 0 (AQP0) is an integral membrane protein that facilitates water transport
and cellular adhesion in the lens. Its dysfunction has been associated with cataractogenesis …

Abstract Aquaporin-5 (AQP5) regulates osmotic balance and transparency of the ocular lens
through facilitated diffusion of water and represents an integral component of the lens …

Lens-specific beaded filament (BF) proteins CP49 and filensin interact with the C-terminus of
the water channel protein Aquaporin 0 (AQP0). Previously we have reported that a C …

Background: Cataracts are defects of the lens that cause progressive visual impairment and
ultimately blindness in many vertebrate species. Most cataracts are age-related, but up to …