Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …

Transposable elements (TEs) are mobile DNA elements that comprise almost 50% of
mammalian genomic sequence. TEs are capable of making additional copies of themselves …

Persistent DNA double-strand breaks (DSBs) in neurons are an early pathological hallmark
of neurodegenerative diseases including Alzheimer's disease (AD), with the potential to …

The multistep process of in vivo reprogramming, mediated by the transcription factors (TFs)
Oct4, Sox2, Klf4, and c-Myc (OSKM), holds great promise for the development of …

Repetitive elements (REs), such as transposable elements (TEs) and satellites, comprise
much of the genome. Here, we review how TEs and (peri) centromeric satellite DNA may …

Aging is considered the deterioration of physiological functions along with an increased
mortality rate. This scientific review focuses on the central importance of genomic instability …

Epigenetic dysregulation emerges as a critical hallmark and driving force of aging. Although
still an evolving field with much to explore, it has rapidly gained significance by providing …

The African turquoise killifish is an emerging vertebrate model organism with great potential
for aging research due to its naturally short lifespan. Thus far, turquoise killifish aging …

Abstract N6‐methyladenosine (m6A) is a dynamic and reversible RNA modification that has
emerged as a crucial player in the life cycle of RNA, thus playing a pivotal role in various …

Transposable elements (TEs) are mobile genetic modules of viral derivation that have been
co-opted to become modulators of mammalian gene expression. TEs are a major source of …