Cardio-oncology: Shared genetic, metabolic, and pharmacologic mechanism
Y Zhao, H Jia, X Hua, T An, J Song - Current Cardiology Reports, 2023 - Springer
Abstract Purpose of Review The article aims to investigate the complex relationship between
cancer and cardiovascular disease (CVD), with a focus on the effects of cancer treatment on …
cancer and cardiovascular disease (CVD), with a focus on the effects of cancer treatment on …
Cell death regulation in myocardial toxicity induced by antineoplastic drugs
X Yu, Y Yang, T Chen, Y Wang, T Guo, Y Liu… - Frontiers in Cell and …, 2023 - frontiersin.org
Homeostatic regulation of cardiomyocytes plays a critical role in maintaining normal
physiological activity of cardiac tissue. Severe cardiotoxicity can lead to heart disease …
physiological activity of cardiac tissue. Severe cardiotoxicity can lead to heart disease …
Clinical trial in a dish: using patient-derived induced pluripotent stem cells to identify risks of drug-induced cardiotoxicity
Drug-induced cardiotoxicity is a significant clinical issue, with many drugs in the market
being labeled with warnings on cardiovascular adverse effects. Treatments are often …
being labeled with warnings on cardiovascular adverse effects. Treatments are often …
Human iPSCs and genome editing technologies for precision cardiovascular tissue engineering
Induced pluripotent stem cells (iPSCs) originate from the reprogramming of adult somatic
cells using four Yamanaka transcription factors. Since their discovery, the stem cell (SC) field …
cells using four Yamanaka transcription factors. Since their discovery, the stem cell (SC) field …
Monoclonal antibody-based immunotherapy and its role in the development of cardiac toxicity
M Kumar, C Thangavel, RC Becker, S Sadayappan - Cancers, 2020 - mdpi.com
Simple Summary The application of immunotherapies to treat cancer patients has
significantly improved over the last two decades and extended many patients' life spans …
significantly improved over the last two decades and extended many patients' life spans …
Building multi-dimensional induced pluripotent stem cells-based model platforms to assess cardiotoxicity in cancer therapies
Cardiovascular disease (CVD) complications have contributed significantly toward poor
survival of cancer patients worldwide. These complications that result in myocardial and …
survival of cancer patients worldwide. These complications that result in myocardial and …
Drug development and the use of induced pluripotent stem cell-derived cardiomyocytes for disease modeling and drug toxicity screening
Over the years, numerous groups have employed human induced pluripotent stem cell-
derived cardiomyocytes (iPSC-CMs) as a superb human-compatible model for investigating …
derived cardiomyocytes (iPSC-CMs) as a superb human-compatible model for investigating …
Heart slice culture system reliably demonstrates clinical drug-related cardiotoxicity
The limited availability of human heart tissue and its complex cell composition are major
limiting factors for the reliable testing of drug efficacy and toxicity. Recently, we developed …
limiting factors for the reliable testing of drug efficacy and toxicity. Recently, we developed …
iPSC-cardiomyocytes in the preclinical prediction of candidate pharmaceutical toxicity
Many challenges remain in the preclinical evaluation, adjudication, and prioritization of
novel compounds in therapeutic discovery pipelines. These obstacles are evident by the …
novel compounds in therapeutic discovery pipelines. These obstacles are evident by the …
Recent advances in pluripotent stem cell-derived cardiac organoids and heart-on-chip applications for studying anti-cancer drug-induced cardiotoxicity
Cardiovascular disease (CVD) caused by anti-cancer drug-induced cardiotoxicity is now the
second leading cause of mortality among cancer survivors. It is necessary to establish …
second leading cause of mortality among cancer survivors. It is necessary to establish …