From selenium to selenoproteins: synthesis, identity, and their role in human health

LV Papp, J Lu, A Holmgren… - Antioxidants & redox …, 2007 - liebertpub.com
The requirement of the trace element selenium for life and its beneficial role in human health
has been known for several decades. This is attributed to low molecular weight selenium …

Focus on mammalian thioredoxin reductases—important selenoproteins with versatile functions

ESJ Arnér - Biochimica et Biophysica Acta (BBA)-General Subjects, 2009 - Elsevier
BACKGROUND: Thioredoxin systems, involving redox active thioredoxins and thioredoxin
reductases, sustain a number of important thioredoxin-dependent pathways. These systems …

Selenium nanoparticles overcomes sorafenib resistance in thioacetamide induced hepatocellular carcinoma in rats by modulation of mTOR, NF-κB pathways and …

TM Al-Noshokaty, NM Mesbah, DM Abo-Elmatty… - Life Sciences, 2022 - Elsevier
Aims The first-line treatment for advanced hepatocellular carcinoma (HCC) is the
multikinase inhibitor sorafenib (SOR). Sofafenib resistance is linked to protein kinase …

Roles of hydrogen peroxide in thyroid physiology and disease

Y Song, N Driessens, M Costa… - The Journal of …, 2007 - academic.oup.com
Context: The long-lived thyroid cell generates, for the synthesis of thyroid hormones,
important amounts of H2O2 that are toxic in other cell types. This review analyzes the …

Selenoproteins and their impact on human health through diverse physiological pathways

B Moghadaszadeh, AH Beggs - Physiology, 2006 - journals.physiology.org
In the last few decades, the importance of selenium in human health has been the subject of
numerous studies. It is believed that the physiological effects of selenium occur mainly …

Biologically significant selenium-containing heterocycles

M Ninomiya, DR Garud, M Koketsu - Coordination Chemistry Reviews, 2011 - Elsevier
Selenium represents an essential element for organisms as various diseases can result from
selenium deficiency. As a consequence, selenium-containing heterocycles are of …

Selenium and the selenoprotein thioredoxin reductase in the prevention, treatment and diagnostics of cancer

M Selenius, AK Rundlöf, E Olm… - Antioxidants & redox …, 2010 - liebertpub.com
Selenium is an essential element that is specifically incorporated as selenocystein into
selenoproteins. It is a potent modulator of eukaryotic cell growth with strictly concentration …

Selenium cytotoxicity in cancer

M Wallenberg, S Misra… - Basic & clinical …, 2014 - Wiley Online Library
Selenium is an essential trace element with growth‐modulating properties. Decades of
research clearly demonstrate that selenium compounds inhibit the growth of malignant cells …

Natural borneol, a monoterpenoid compound, potentiates selenocystine-induced apoptosis in human hepatocellular carcinoma cells by enhancement of cellular …

J Su, H Lai, J Chen, L Li, YS Wong, T Chen, X Li - PLoS One, 2013 - journals.plos.org
Selenocystine (SeC) has been identified as a novel compound with broad-spectrum
anticancer activities. Natural borneol (NB) is a monoterpenoid compound that has been …

Observational epidemiologic studies of nutrition and cancer: the next generation (with better observation)

A Schatzkin, AF Subar, S Moore, Y Park… - … biomarkers & prevention, 2009 - AACR
It would be of enormous public health importance if diet and physical activity, both
modifiable behavioral factors, were causally related to cancer. Nevertheless, the nutritional …