Dosage effects of ZP2 and ZP3 heterozygous mutations cause human infertility

W Liu, K Li, D Bai, J Yin, Y Tang, F Chi, L Zhang… - Human Genetics, 2017 - Springer
The zona pellucida (ZP) is an extracellular matrix universally surrounding mammalian eggs,
which is essential for oogenesis, fertilization, and pre-implantation embryo development …

Mutant Zp1 impedes incorporation of ZP3 and ZP4 in the zona pellucida, resulting in zona absence and female infertility in rats

C Lv, HL Huang, DJ Yi, TL Peng, HJ Tan… - Biology of …, 2021 - academic.oup.com
The zona pellucida (ZP) plays vital roles in reproductive processes including oogenesis,
fertilization, and preimplantation development. Both human and rat ZP consist of four …

Case Report: A Novel Heterozygous ZP3 Deletion Associated With Empty Follicle Syndrome and Abnormal Follicular Development

Y Chen, Z Wang, Y Wu, W He, J Du, S Cai… - Frontiers in …, 2021 - frontiersin.org
Background: Empty follicle syndrome (EFS) is defined as the complete failure to retrieve
oocytes after ovarian stimulation. Although several mutations in ZP1, ZP2, ZP3, and LHCGR …

Case report: A novel homozygous variant in ZP3 is associated with human empty follicle syndrome

N Kong, Q Xu, X Shen, X Zhu, G Cao - Frontiers in Genetics, 2023 - frontiersin.org
Empty follicle syndrome (EFS) is a rare condition in female infertility. It is characterized by
the inability to retrieve oocytes from visibly large, normally developing follicles in the ovaries …

[PDF][PDF] The morphology of porcine oocytes is associated with zona pellucida glycoprotein 3 and integrin beta 2 protein levels--

P Antosik, B Kempisty, M Jackowska… - Veterinární …, 2010 - agriculturejournals.cz
The morphology and quality of oocytes is set during oo-and folliculo-genesis, and is
completed during final maturation. Early embryonic development is associated with the …

ZP1-Y262C mutation causes abnormal zona pellucida formation and female infertility in humans

G Cao, L Yu, J Fang, R Shi, H Li, F Lu, X Shen… - Frontiers in …, 2024 - frontiersin.org
Defective oocyte maturation is a common cause of female infertility. The loss of the zona
pellucida (ZP) represents a specific condition of impaired oocyte maturation. The …

Effect of Mare Age on Transcript Abundance of Connexins-37 and-43, Zona Pellucida Proteins, and Sperm Binding

DR Bresnahan, RE Lupole, CR Stilz… - Journal of Equine …, 2022 - Elsevier
Zona pellucida (ZP) proteins are important for fertilization and sperm binding and are closely
associated with cumulus cells. Communication between cumulus and oocytes is facilitated …

Sperm capacitation, the acrosome reaction, and fertilization

P Sutovsky - … and Infertility: Integrating Modern Clinical and …, 2010 - Springer
Recent advances in our understanding of fertilization are summarized, highlighting newly
discovered molecules implicated in sperm interactions with the epithelia of the female …

RNA interference and ovarian functions

AV Sirotkin - Journal of cellular physiology, 2010 - Wiley Online Library
RNA interference, a recently discovered new mechanism controlling gene expression via
small RNAs, was shown to be involved in characterization and control of basic ovarian cell …

Application of RNA interference for the control of female reproductive functions

AV Sirotkin - Current pharmaceutical design, 2012 - ingentaconnect.com
RNA interference, a recently discovered new mechanism controlling gene expression via
small RNAs, was shown to be involved in the characterization and control of basic ovarian …