Pneumonia and its sequelae, acute lung injury, present unique challenges for pulmonary
and critical care healthcare professionals, and these challenges have recently garnered …

Alveolar type II (ATII) cells are a key structure of the distal lung epithelium, where they exert
their innate immune response and serve as progenitors of alveolar type I (ATI) cells …

Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease arising from impaired
regeneration of the alveolar epithelium after injury. During regeneration, type 2 alveolar …

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease characterized by
excessive proliferation of fibroblasts and excessive accumulation of extracellular matrix …

The human lung plays vital roles in respiration, host defense, and basic physiology. Recent
technological advancements such as single-cell RNA sequencing and genetic lineage …

Pulmonary surfactant is a critical component of lung function in healthy individuals. It
functions in part by lowering surface tension in the alveoli, thereby allowing for breathing …

Although alveolar epithelial cells play a critical role in the pathogenesis of pulmonary
fibrosis, few practical in vitro models exist to study them. Here, we established a novel in …

Abstract Interleukin (IL)-11 evolved as part of the innate immune response. In the human
lung, IL-11 upregulation has been associated with viral infections and a range of …

Pulmonary diseases are main causes of morbidity and mortality worldwide. Current studies
show that though specific pulmonary diseases and correlative lung-metabolic deviance own …

Rationale: A prevailing paradigm recognizes idiopathic pulmonary fibrosis (IPF) originating
from various alveolar epithelial cell (AEC) injuries, and there is a growing appreciation of …