Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality
worldwide. COPD heterogeneity has hampered progress in developing pharmacotherapies …

Respiratory viral infections are a major public health problem, with much of their morbidity
and mortality due to post-viral lung diseases that progress and persist after the active …

Rationale: CFTR (cystic fibrosis transmembrane conductance regulator) dysfunction is
associated with mucus accumulation and worsening chronic obstructive pulmonary disease …

Rationale COPD is characterized by chronic airway inflammation, small airways changes,
with disappearance and obstruction, and also distal/alveolar destruction (emphysema). The …

BACKGROUND Information about the size, airway location, and longitudinal behavior of
mucus plugs in asthma is needed to understand their role in mechanisms of airflow …

Airway mucus is a hydrogel with unique biophysical properties due to its primary water
composition and a small proportion of large anionic glycoproteins or mucins. The …

To date, the treatable traits (TTs) approach has been applied in the context of managing
diagnosed diseases. TTs are clinical characteristics and risk factors that can be identified …

Background Airway mucus plugs are frequently identified on CT scans of patients with
COPD with a smoking history without mucus-related symptoms (ie, cough, phlegm [silent …

Muco-obstructive diseases change airway mucus properties, impairing mucociliary transport
and increasing the likelihood of infections. To investigate the sorption properties and …

Paediatric Mycoplasma pneumoniae pneumonia (MPP) is a heterogeneous disease with a
diverse spectrum of clinical phenotypes. No studies have demonstrated the relationship …