Select Drug-Drug Interactions With Direct Oral Anticoagulants: JACC Review Topic of the Week

BS Wiggins, DL Dixon, RR Neyens, RL Page… - Journal of the American …, 2020 - jacc.org
Millions of individuals in the United States require long-term treatment with an oral
anticoagulant. For decades, vitamin K antagonists were the only oral option available; …

Atrial fibrillation and cancer patients: mechanisms and management

DL Madnick, MG Fradley - Current Cardiology Reports, 2022 - Springer
Abstract Purpose of Review Cancer-related mortality has significantly declined over the past
several decades as a result of improved screening, diagnostics, and therapeutics. Although …

Bleeding risk in hemodialysis patients

AE van der Sluijs, P Pai, W Zhu, G Ocak - Seminars in Nephrology, 2024 - Elsevier
Cardiovascular diseases are highly prevalent among patients on dialysis. For these
diseases, antiplatelets and antithrombotic therapies including heparin, vitamin K …

Management of outpatient warfarin therapy amid COVID-19 pandemic: a practical guide

CS Kow, W Sunter, A Bain, STR Zaidi… - American Journal of …, 2020 - Springer
Many healthcare resources have been and continue to be allocated to the management of
patients with COVID-19. Therefore, the ongoing care of patients receiving oral …

Direct oral anticoagulants (DOACs) for therapeutic targeting of thrombin, a key mediator of cerebrovascular and neuronal dysfunction in Alzheimer's disease

K Grossmann - Biomedicines, 2022 - mdpi.com
Although preclinical research and observer studies on patients with atrial fibrillation
concluded that direct oral anticoagulants (DOACs) can protect against dementia like …

Warfarin and vitamin K epoxide reductase: a molecular accounting for observed inhibition

S Wu, X Chen, DY Jin, DW Stafford… - Blood, The Journal …, 2018 - ashpublications.org
Vitamin K epoxide reductase (VKOR), an endoplasmic reticulum membrane protein, is the
key enzyme for vitamin K–dependent carboxylation, a posttranslational modification that is …

Assessing major bleeding risk in atrial fibrillation patients concurrently taking non-vitamin K antagonist oral anticoagulants and antiepileptic drugs

CL Wang, VCC Wu, KH Chang, HT Tu… - European Heart …, 2020 - academic.oup.com
Aims This study compared the risk of major bleeding between atrial fibrillation (AF) patients
who took non-vitamin K antagonist oral anticoagulants (NOACs) and antiepileptic drugs …

Direct oral anticoagulant treatment and mild traumatic brain injury: risk of early and delayed bleeding and the severity of injuries compared with vitamin K antagonists

G Turcato, M Zannoni, A Zaboli, E Zorzi, G Ricci… - The Journal of …, 2019 - Elsevier
Background The risk of intracranial hemorrhage (ICH) in patients taking direct oral
anticoagulants (DOACs) after mild traumatic brain injury (MTBI) is unclear. Objectives To …

Racial and Ethnic Disparities in Initiation of Direct Oral Anticoagulants Among Medicare Beneficiaries

KR Reynolds, F Khosrow-Khavar… - JAMA Network Open, 2024 - jamanetwork.com
Importance The influence of race and ethnicity on initiation of direct oral anticoagulants
(DOACs) is relatively understudied in Medicare data. Objective To investigate disparities in …

A Descriptive Analysis of Direct Oral Anticoagulant Drugs dosing errors based on spontaneous reports from the EudraVigilance database

C Morgovan, CM Dobrea, AA Chis, AM Juncan… - Pharmaceuticals, 2023 - mdpi.com
Direct oral anticoagulant drugs (DOACs) interfere with the coagulation process, thus
improving patient care for those who require anticoagulant treatment. This study presents a …