Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy
W Gao, X Wang, Y Zhou, X Wang, Y Yu - Signal transduction and …, 2022 - nature.com
In recent years, immunotherapy represented by immune checkpoint inhibitors (ICIs) has led
to unprecedented breakthroughs in cancer treatment. However, the fact that many tumors …
to unprecedented breakthroughs in cancer treatment. However, the fact that many tumors …
Targeting autophagy in cancer
JMM Levy, CG Towers, A Thorburn - Nature Reviews Cancer, 2017 - nature.com
Autophagy is a mechanism by which cellular material is delivered to lysosomes for
degradation, leading to the basal turnover of cell components and providing energy and …
degradation, leading to the basal turnover of cell components and providing energy and …
A metal‐organic framework (MOF) Fenton nanoagent‐enabled nanocatalytic cancer therapy in synergy with autophagy inhibition
Nanocatalytic medicine has been developed recently to trigger intratumoral generation of
highly toxic reactive oxygen species (ROS) for cancer therapy, which, unfortunately, suffers …
highly toxic reactive oxygen species (ROS) for cancer therapy, which, unfortunately, suffers …
[HTML][HTML] Role and regulation of autophagy in cancer
R Rakesh, LC PriyaDharshini, KM Sakthivel… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Autophagy is an intracellular self-degradative mechanism which responds to cellular
conditions like stress or starvation and plays a key role in regulating cell metabolism, energy …
conditions like stress or starvation and plays a key role in regulating cell metabolism, energy …
Targeting autophagy in disease: established and new strategies
Macroautophagy/autophagy is an evolutionarily conserved pathway responsible for clearing
cytosolic aggregated proteins, damaged organelles or invading microorganisms …
cytosolic aggregated proteins, damaged organelles or invading microorganisms …
Dual role of autophagy in hallmarks of cancer
Evolutionarily conserved across eukaryotic cells, macroautophagy (herein autophagy) is an
intracellular catabolic degradative process targeting damaged and superfluous cellular …
intracellular catabolic degradative process targeting damaged and superfluous cellular …
Autophagy and cancer stem cells: molecular mechanisms and therapeutic applications
F Nazio, M Bordi, V Cianfanelli, F Locatelli… - Cell Death & …, 2019 - nature.com
Autophagy and mitophagy act in cancer as bimodal processes, whose differential functions
strictly depend on cancer ontogenesis, progression, and type. For instance, they can act to …
strictly depend on cancer ontogenesis, progression, and type. For instance, they can act to …
Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation
Major depressive disorder (MDD) is a life‐threatening illness characterized by mood
changes and high rates of suicide. Although the role of neuroinflammation in MMD has been …
changes and high rates of suicide. Although the role of neuroinflammation in MMD has been …
Anticancer activity of complexes of the third row transition metals, rhenium, osmium, and iridium
The clinical success of the platinum-based chemotherapeutic agents has prompted the
investigation of coordination and organometallic complexes of alternative metal centers for …
investigation of coordination and organometallic complexes of alternative metal centers for …
The pharmacological regulation of cellular mitophagy
ND Georgakopoulos, G Wells… - Nature chemical biology, 2017 - nature.com
Small molecules are pharmacological tools of considerable value for dissecting complex
biological processes and identifying potential therapeutic interventions. Recently, the …
biological processes and identifying potential therapeutic interventions. Recently, the …