The nature of the transition from acute to chronic pain still eludes explanation, but chronic
pain resulting from surgery provides a natural experiment that invites clinical …

After nerve injury maladaptive changes can occur in injured sensory neurons and along the
entire nociceptive pathway within the CNS, which may lead to spontaneous pain or pain …

Chronic pain is a global problem that has reached epidemic proportions. An estimated 20%
of adults suffer from pain, and another 10% are diagnosed with chronic pain each year …

Many pain states begin with damage to tissue and/or nerves in the periphery, leading to
enhanced transmitter release within the spinal cord and central sensitization. Manifestations …

Spinal long-term potentiation (LTP) at C-fiber synapses is hypothesized to underlie chronic
pain. However, a causal link between spinal LTP and chronic pain is still lacking. Here, we …

The nociceptive system adapts readily to the varying needs of a warning system for
maintenance of bodily integrity. It often decreases its sensitivity upon continuous …

Background As in other fields of medicine, development of new medications for
management of neuropathic pain has been difficult since preclinical rodent models do not …

Quantitative sensory testing (QST) is a formal variant of a time-honoured clinical
examination technique in neurology, the sensory examination. Prototypical QST profiles …

Long-term potentiation of synaptic strength (LTP) in nociceptive pathways shares principle
features with hyperalgesia including induction protocols, pharmacological profile, neuronal …

2. Background In the 19th and 20th century, there was a heated debate (for review, see Ref.
7) whether the presence of noxious stimuli is signaled by specific receptors and neural …