[HTML][HTML] Heterochromatin: an epigenetic point of view in aging
Aging is an inevitable process of life. Defined by progressive physiological and functional
loss of tissues and organs, aging increases the risk of mortality for the organism. The aging …
loss of tissues and organs, aging increases the risk of mortality for the organism. The aging …
[HTML][HTML] Human RecQ helicases in DNA double-strand break repair
RecQ DNA helicases are a conserved protein family found in bacteria, fungus, plants, and
animals. These helicases play important roles in multiple cellular functions, including DNA …
animals. These helicases play important roles in multiple cellular functions, including DNA …
METTL3 counteracts premature aging via m6A-dependent stabilization of MIS12 mRNA
Z Wu, Y Shi, M Lu, M Song, Z Yu, J Wang… - Nucleic acids …, 2020 - academic.oup.com
Abstract N6-Methyladenosine (m6A) messenger RNA methylation is a well-known
epitranscriptional regulatory mechanism affecting central biological processes, but its …
epitranscriptional regulatory mechanism affecting central biological processes, but its …
[HTML][HTML] NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome
Metabolic dysfunction is a primary feature of Werner syndrome (WS), a human premature
aging disease caused by mutations in the gene encoding the Werner (WRN) DNA helicase …
aging disease caused by mutations in the gene encoding the Werner (WRN) DNA helicase …
Chemical screen identifies a geroprotective role of quercetin in premature aging
Aging increases the risk of various diseases. The main goal of aging research is to find
therapies that attenuate aging and alleviate aging-related diseases. In this study, we …
therapies that attenuate aging and alleviate aging-related diseases. In this study, we …
[HTML][HTML] Vitamin C: a review on its role in the management of metabolic syndrome
Oxidative stress and inflammation are two interlinked events that exist simultaneously in
metabolic syndrome (MetS) and its related complications. These pathophysiological …
metabolic syndrome (MetS) and its related complications. These pathophysiological …
Mitochondrial functions and rare diseases
L Dard, W Blanchard, C Hubert, D Lacombe… - Molecular Aspects of …, 2020 - Elsevier
Mitochondria are dynamic cellular organelles responsible for a large variety of biochemical
processes as energy transduction, REDOX signaling, the biosynthesis of hormones and …
processes as energy transduction, REDOX signaling, the biosynthesis of hormones and …
Plugged into the Ku-DNA hub: The NHEJ network
P Frit, V Ropars, M Modesti, JB Charbonnier… - Progress in biophysics …, 2019 - Elsevier
In vertebrates, double-strand breaks in DNA are primarily repaired by Non-Homologous End-
Joining (NHEJ). The ring-shaped Ku heterodimer rapidly senses and threads onto broken …
Joining (NHEJ). The ring-shaped Ku heterodimer rapidly senses and threads onto broken …
[HTML][HTML] WRN promotes bone development and growth by unwinding SHOX-G-quadruplexes via its helicase activity in Werner Syndrome
Werner Syndrome (WS) is an autosomal recessive disorder characterized by premature
aging due to mutations of the WRN gene. A classical sign in WS patients is short stature, but …
aging due to mutations of the WRN gene. A classical sign in WS patients is short stature, but …
The Ku complex: recent advances and emerging roles outside of non-homologous end-joining
S Abbasi, G Parmar, RD Kelly, N Balasuriya… - Cellular and Molecular …, 2021 - Springer
Since its discovery in 1981, the Ku complex has been extensively studied under multiple
cellular contexts, with most work focusing on Ku in terms of its essential role in non …
cellular contexts, with most work focusing on Ku in terms of its essential role in non …