New microfluidic systems for whole organism analysis and experimentation are catalyzing
biological breakthroughs across many fields, from human health to fundamental biology …

In a typical high-throughput drug screening (HTS) process, up to millions of chemical
compounds are applied to cells cultured in well plates, aiming to find molecules that exhibit …

Although much is known about the biochemical regulation of glycolytic enzymes, less is
understood about how they are organized inside cells. We systematically examine the …

Biological sex, a fundamental dimension of internal state, can modulate neural circuits to
generate behavioral variation. Understanding how and why circuits are tuned by sex can …

Parkinson's disease (PD) is a progressive neurological disorder associated with the loss of
dopaminergic neurons (DNs) in the substantia nigra and the widespread accumulation of α …

We demonstrate diffraction-limited and super-resolution imaging through thick layers (tens-
hundreds of microns) of BIO-133, a biocompatible, UV-curable, commercially available …

Sleep, a state of quiescence associated with growth and restorative processes, is conserved
across species. Invertebrates including the nematode Caenorhabditis elegans exhibit sleep …

The development and application of methods for automated behavioral analysis have
revolutionized behavioral genetics across model organisms. In this review we summarize …

This paper reports a vision-based automated microfluidic system for morphological
measurement and size-based sorting of the nematode worm C. elegans. Exceeding the …

The use of calcium indicators has greatly enhanced our understanding of neural dynamics
and regulation. The nematode Caenorhabditis elegans, with its completely mapped nervous …