Metabolomics is a dynamic tool for elucidating biochemical changes in human health and
disease. Metabolic profiles provide a close insight into physiological states and are highly …

The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) plays a
critical role in the maintenance of cellular redox and metabolic homeostasis, as well as the …

Liquid chromatography-mass spectrometry (LC-MS) is the method of choice for the
untargeted profiling of biological samples. A multiplatform LC-MS-based approach is …

Metabolomics holds great promise for uncovering insights around biological processes
impacting disease in human epidemiological studies. Metabolites can be measured across …

Mitochondrial disorders are monogenic disorders characterized by a defect in oxidative
phosphorylation and caused by pathogenic variants in one of over 340 different genes. The …

Health effects of pesticides are not always accurately detected using the current battery of
regulatory toxicity tests. We compared standard histopathology and serum biochemistry …

Metabolic reprogramming is increasingly recognised as one of the defining hallmarks of
tumorigenesis. There is compelling evidence to suggest that endometrial cancer develops …

Metabolomics is a fundamental approach to discovering novel biomarkers and their
potential use for precision medicine. When applied for population screening, NMR-based …

Liquid biopsy, through isolation and analysis of disease-specific analytes, has evolved as a
promising tool for safe and minimally invasive diagnosis and monitoring of tumors. It also …

Artificial intelligence (AI) refers to the simulation of human intelligence in machines, using
machine learning (ML), deep learning (DL) and neural networks (NNs). AI enables …