Antibodies of IgG4 subclass are exceptional players of the immune system, as they are
considered to be immunologically inert and functionally monovalent, and as such may be …

Membranous nephropathy (MN) is the major cause of nephrotic syndrome with special
pathological features, caused by the formation of immune complexes in the space between …

The membrane attack complex—also known as C5b-9—is the end-product of the classical,
lectin, and alternative complement pathways. It is thought to play an important role in the …

IgG4 autoimmune diseases are characterized by the presence of antigen-specific
autoantibodies of the IgG4 subclass and contain well-characterized diseases such as …

It has long been known that the complement cascade is activated in various forms of
glomerulonephritis. In many of these diseases, immune-complexes deposit in the glomeruli …

Background Total coumarins extracted from Hydrangea. Paniculata, Sieb (HP) have showed
renal protective effect in several experimental acute and chronic kidney diseases. Purpose …

The complement system is well known for its role in innate immunity and in maintenance of
tissue homeostasis, providing a first line of defence against infection and playing a key role …

The phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A
(THSD7A) are the two major autoantigens in primary membranous nephropathy (MN), and …

Primary membranous nephropathy (MN) is an auto-immune glomerular disease which is
characterized histologically by uniform thickening of the glomerular capillary due to the …

The distinguishing of the IgG4-related disease (IgG4-RD) from among other rheumatic
diseases has brought attention to the IgG4 subclass of immunoglobulins. It is the least …