Altered intestinal microbial flora and metabolism in patients with idiopathic membranous nephropathy

X Shi, Z Li, W Lin, W Shi, R Hu, G Chen, X Li… - American Journal of …, 2023 - karger.com
Introduction: Dysbiosis of the intestinal microbiome and related metabolites have been
observed in chronic kidney disease, yet their roles in idiopathic membranous nephropathy …

[HTML][HTML] Mechanisms of primary membranous nephropathy

Y Gu, H Xu, D Tang - Biomolecules, 2021 - mdpi.com
Membranous nephropathy (MN) is an autoimmune disease of the kidney glomerulus and
one of the leading causes of nephrotic syndrome. The disease exhibits heterogenous …

[HTML][HTML] Proteomic analysis of complement proteins in membranous nephropathy

A Ravindran, B Madden, MC Charlesworth… - Kidney international …, 2020 - Elsevier
Introduction Membranous nephropathy (MN) is the most common cause of nephrotic
syndrome in Caucasian adults. Phospholipase A2 receptor (PLA2R)–and exostosin 1 …

Phospholipase A2 receptor–related membranous nephropathy and mannan-binding lectin deficiency

S Bally, H Debiec, D Ponard, F Dijoud… - Journal of the …, 2016 - journals.lww.com
Most patients with idiopathic membranous nephropathy (IMN) have IgG4 autoantibodies
against phospholipase A2 receptor (PLA2R). C3 and C5b-9 are found in immune deposits of …

Molecular pathogenesis of membranous nephropathy

P Ronco, H Debiec - Annual Review of Pathology: Mechanisms …, 2020 - annualreviews.org
Membranous nephropathy is a noninflammatory autoimmune disease of the kidney
glomerulus, characterized by the formation of immune deposits, complement-mediated …

[HTML][HTML] Single-cell profiling reveals transcriptional signatures and cell-cell crosstalk in anti-PLA2R positive idiopathic membranous nephropathy patients

J Xu, C Shen, W Lin, T Meng, JD Ooi… - Frontiers in …, 2021 - frontiersin.org
Idiopathic membranous nephropathy (IMN) is an organ-specific autoimmune disease of the
kidney glomerulus. It may gradually progress to end-stage renal disease (ESRD) …

[HTML][HTML] Complement activation products in the circulation and urine of primary membranous nephropathy

M Zhang, J Huang, Y Zhang, Z Qu, X Wang, F Wang… - BMC nephrology, 2019 - Springer
Background Complement activation plays a substantial role in the pathogenesis of primary
membranous nephropathy (pMN). C5b-9, C3c, MBL, and factor B have been documented in …

Gut microbiota enhances the chemosensitivity of hepatocellular carcinoma to 5‐fluorouracil in vivo by increasing curcumin bioavailability

M Jin, L Kong, Y Han, S Zhang - Phytotherapy Research, 2021 - Wiley Online Library
5‐Fluorouracil (5‐Fu) is efficient for hepatocellular carcinoma (HCC) treatment, but fast‐
emerging resistance limits its usage. Curcumin is being investigated for its potential …

Long noncoding RNA Kcnq1ot1 promotes sC5b-9-induced podocyte pyroptosis by inhibiting miR-486a-3p and upregulating NLRP3

C Zhang, Y Gong, N Li, X Liu, Y Zhang… - … of Physiology-Cell …, 2021 - journals.physiology.org
Podocytes are epithelial cells adhering glomerular capillaries, which regulate the integrity of
glomerular filtration barrier. Irreversible podocyte injury induces glomerular inflammation …

[HTML][HTML] Complement dysregulation in glomerulonephritis

K Kaartinen, A Safa, S Kotha, G Ratti, S Meri - Seminars in immunology, 2019 - Elsevier
Glomerulonephritis (GN) refers to a group of renal diseases affecting the glomeruli due to
the damage mediated by immunological mechanisms. A large proportion of the disease …