The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to
import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in …

The gut microbiota contributes to host physiology through the production of a myriad of
metabolites. These metabolites exert their effects within the host as signalling molecules and …

Ferroptosis, an iron-dependent nonapoptotic cell death, is a highly regulated tumor
suppressing process. However, functions and mechanisms of RNA-binding proteins in …

SLC7A11/xCT is an antiporter that mediates the uptake of extracellular cystine in exchange
for glutamate. Cystine is reduced to cysteine, which is a rate-limiting precursor in glutathione …

While cost-effective high-throughput technologies provide an increasing amount of data, the
analyses of single layers of data seldom provide causal relations. Multi-omics data …

Plants frequently have to weather both biotic and abiotic stressors, and have evolved
sophisticated adaptation and defense mechanisms. In recent years, chromatin modifications …

Fusarium head blight (FHB) of small grain cereals caused by Fusarium graminearum and
other Fusarium species is an economically important plant disease worldwide. Fusarium …

This year is the tenth anniversary of the publication in this journal of a model suggesting the
existence of'tumour progenitor genes'. These genes are epigenetically disrupted at the …

CD4+ T cells differentiate and acquire distinct functions to combat specific pathogens but
can also adapt their functions in response to changing circumstances. Although this …

Histone modifications and chromatin-associated protein complexes are crucially involved in
the control of gene expression, supervising cell fate decisions and differentiation. Many …