Ferroptosis, a unique form of regulated necrotic cell death, is caused by excessive iron-
dependent lipid peroxidation. However, the underlying mechanisms driving ferroptosis in …

Recent data support the view that epigenetic processes play a role in memory consolidation
and help to transmit acquired memories even across generations in a Lamarckian manner …

Here we show that bivalent domains and chromosome architecture for bivalent genes are
dynamically regulated during the cell cycle in human pluripotent cells. Central to this is the …

Post-traumatic stress disorder (PTSD) and other anxiety disorders stemming from
dysregulated fear memory are problematic and costly. Understanding the molecular …

In pluripotent stem cells, the interplay between signaling cues, epigenetic regulators and
transcription factors orchestrates developmental potency. Flexibility in gene expression …

The amyloid cascade hypothesis for the pathogenesis of Alzheimer's disease (AD) was
proposed over twenty years ago. However, the mechanisms of neurodegeneration and …

AMP-activated protein kinase (AMPK) and its yeast homolog, Snf1, are critical regulators in
the maintenance of energy metabolic balance not only stimulating energy production but …

Histones are important component of eukaryotic cells chromatin and consist of arginine and
lysine residues. Histones play an important role in the protection of DNA. Their contents …

The vitamin D3 metabolite 1α, 25-dihydroxyvitamin D3 [1, 25 (OH) 2D3] is the exclusive high-
affinity ligand of the vitamin D receptor (VDR), a transcription factor with direct effects on …

As sessile organisms, plants are exposed to environmental stresses throughout their life.
They have developed survival strategies such as developmental and morphological …