This 2023 statement updates clinical guidance for homozygous familial
hypercholesterolaemia (HoFH), explains the genetic complexity, and provides pragmatic …

Abstract Aims Homozygous familial hypercholesterolaemia (HoFH) is a rare life-threatening
condition characterized by markedly elevated circulating levels of low-density lipoprotein …

Nonalcoholic fatty liver disease (NAFLD) is common and partially heritable and has no
effective treatments. We carried out a genome-wide association study (GWAS) meta …

Material de distribuição exclusiva à classe médica. Os Arquivos Brasileiros de Cardiologia
não se responsabilizam pelo acesso indevido a seu conteúdo e que contrarie a …

Nonalcoholic Fatty Liver Disease (NAFLD) represents the leading cause of liver disease in
developed countries but its diffusion is currently also emerging in Asian countries, in South …

An increased risk of cardiovascular disease, independent of conventional risk factors, is
present even at minor levels of renal impairment and is highest in patients with end-stage …

Triglycerides are exclusively transported with chylomicrons and this process is critically
dependent on MTP. In addition to chylomicrons, absorption of phospholipids, free …

Sphingolipids are structurally and functionally diverse molecules with significant physiologic
functions and are found associated with cellular membranes and plasma lipoproteins. The …

Carbohydrate response element-binding protein (ChREBP) plays an important role in the
development of type 2 diabetes, dyslipidemia, and non-alcoholic fatty liver disease, as well …

Background and Aims Human transmembrane 6 superfamily 2 (TM6SF2) variant
rs58542926 is associated with NAFLD and HCC. However, conflicting reports in germline …