[HTML][HTML] Response and resistance to BCR-ABL1-targeted therapies
TP Braun, CA Eide, BJ Druker - Cancer cell, 2020 - cell.com
Chronic myeloid leukemia (CML), caused by constitutively active BCR-ABL1 fusion tyrosine
kinase, has served as a paradigm for successful application of molecularly targeted cancer …
kinase, has served as a paradigm for successful application of molecularly targeted cancer …
[HTML][HTML] Chronic myeloid leukemia: a model disease of the past, present and future
VR Minciacchi, R Kumar, DS Krause - Cells, 2021 - mdpi.com
Chronic myeloid leukemia (CML) has been a “model disease” with a long history. Beginning
with the first discovery of leukemia and the description of the Philadelphia Chromosome and …
with the first discovery of leukemia and the description of the Philadelphia Chromosome and …
Chronic Myeloid Leukemia: Modern therapies, current challenges and future directions
AEG Osman, MW Deininger - Blood reviews, 2021 - Elsevier
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm caused by a reciprocal
translocation [t (9; 22)(q34; q11. 2)] that leads to the fusion of ABL1 gene sequences (9q34) …
translocation [t (9; 22)(q34; q11. 2)] that leads to the fusion of ABL1 gene sequences (9q34) …
A phase 2 trial of ponatinib in Philadelphia chromosome–positive leukemias
JE Cortes, DW Kim, J Pinilla-Ibarz… - … England Journal of …, 2013 - Mass Medical Soc
Background Ponatinib is a potent oral tyrosine kinase inhibitor of unmutated and mutated
BCR-ABL, including BCR-ABL with the tyrosine kinase inhibitor–refractory threonine-to …
BCR-ABL, including BCR-ABL with the tyrosine kinase inhibitor–refractory threonine-to …
[HTML][HTML] The Philadelphia chromosome in leukemogenesis
ZJ Kang, YF Liu, LZ Xu, ZJ Long, D Huang… - Chinese journal of …, 2016 - Springer
The truncated chromosome 22 that results from the reciprocal translocation t (9; 22)(q34;
q11) is known as the Philadelphia chromosome (Ph) and is a hallmark of chronic myeloid …
q11) is known as the Philadelphia chromosome (Ph) and is a hallmark of chronic myeloid …
The impact of translocations and gene fusions on cancer causation
F Mitelman, B Johansson, F Mertens - Nature Reviews Cancer, 2007 - nature.com
Chromosome aberrations, in particular translocations and their corresponding gene fusions,
have an important role in the initial steps of tumorigenesis; at present, 358 gene fusions …
have an important role in the initial steps of tumorigenesis; at present, 358 gene fusions …
Molecular biology of bcr-abl1–positive chronic myeloid leukemia
A Quintás-Cardama, J Cortes - Blood, The Journal of the …, 2009 - ashpublications.org
Chronic myeloid leukemia (CML) has been regarded as the paradigmatic example of a
malignancy defined by a unique molecular event, the BCR-ABL1 oncogene. Decades of …
malignancy defined by a unique molecular event, the BCR-ABL1 oncogene. Decades of …
Chronic myeloid leukemia—advances in biology and new approaches to treatment
JM Goldman, JV Melo - New England Journal of Medicine, 2003 - Mass Medical Soc
An extraordinary series of discoveries about chronic myeloid leukemia (CML) has made this
disease a model of the way in which bench and bedside research can unite and culminate …
disease a model of the way in which bench and bedside research can unite and culminate …
The pharmacology and clinical pharmacology of 3, 4-methylenedioxymethamphetamine (MDMA,“ecstasy”)
AR Green, AO Mechan, JM Elliott, E O'Shea… - Pharmacological …, 2003 - ASPET
The amphetamine derivative (±)-3, 4-methylenedioxymethamphetamine (MDMA, ecstasy) is
a popular recreational drug among young people, particularly those involved in the dance …
a popular recreational drug among young people, particularly those involved in the dance …
Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1
MG Ott, M Schmidt, K Schwarzwaelder, S Stein… - Nature medicine, 2006 - nature.com
Gene transfer into hematopoietic stem cells has been used successfully for correcting
lymphoid but not myeloid immunodeficiencies. Here we report on two adults who received …
lymphoid but not myeloid immunodeficiencies. Here we report on two adults who received …