Therapeutic drug monitoring is an integral part of services offered by toxicology laboratories
because certain drugs require routine monitoring for dosage adjustment to achieve optimal …

The determination of antidepressant drugs which act by blocking neuronal uptake of
biogenic amines, because of their widespread use and high toxicity, remains one of the most …

A single rapid and specific solid-phase clean-up procedure was developed for the analysis
of benzodiazepines and tricyclic antidepressants using a carefully selected wash step and …

For drugs with a narrow therapeutic index, therapeutic drug monitoring methods are
essential for patient management. Although immunoassays are commercially available for …

We employed a new form of solid-phase material, the Empore® octyl (C8) extraction
membrane (SPEM), for the efficient extraction of tricyclic drugs from patients' serum …

Solid-phase extraction (SPE) was coupled at-line to capillary electrophoresis (CE) for the
determination of a series of basic test compounds (ie tricyclic antidepressants). The analysis …

A method for the detection of benzoylecgonine (cocaine metabolite) and opiates in whole
blood is described. This method employs the Abbott TDx fluorescence polarization …

Human urine was tested for tricyclic antidepressants with fluorescence polarization
immunoassay (FPIA) reagents on Abbott's ADx system and with EIA reagents on Syva's ETS …

A new approach for the quantitation of drugs, based on the measurement of the critical
micelle concentration of mixed surfactant–drug aggregates, is proposed. This methodology …

Several methods were developed for the simultaneous determination of the binary mixtures
amitriptyline—imipramine (1.00–10 μg ml− 1), amitriptyline—perphenazine (1.00–30.00 and …