Background Osteoarthritis (OA) is a worldwide musculoskeletal disorder. However, disease-
modifying therapies for OA are not available. Here, we aimed to characterize the molecular …

The cardiac glycoside, digoxin, is clinically used to treat fetal tachyarrhythmias and
congestive heart failure. The time course of digoxin transfer across the human placenta was …

The importance of high specificity in immunoassays used in therapeutic monitoring is
highlighted by a case study in which therapeutic-to-toxic borderline digoxin levels were …

Asian medicines are widely used as alternative medicine. However, interactions between
drugs and Asian medicines have been poorly studied. Chan Su and Lu-Shen-Wan are …

Abstract Digoxin fab antibody (Digibind; Burroughs Wellcome, Research Triangle Park, NC,
USA) is used in the treatment of digoxin overdose. The effect of digibind on the …

Epithelial cells play a major role in animal and human homeostasis because they selectively
regulate the exchange of solutes between two given media, such as blood or urine. Cardiac …

Background Digitoxin and valproic acid show strong binding to serum albumin. Thus, when
present simultaneously in serum, digitoxin and valproic acid compete for binding sites. We …

Endogeneous digoxin-like immunoreactive factors (DLIF) can interfere with some digoxin
immunoassays. We looked for similar interference, called digitoxin-like immunoreactive …

Papers from the Second International Conference on TDM Toxicology (date and place not
stated) describe research on various aspects of therapeutic monitoring pharmacology …

We have biotinylated the terminal glycose of digoxin by reaction of the periodate-oxidized
steroid with biotin hydrazide. A biotinylated product (BD-1) was formed which retained …