[HTML][HTML] Molecular and phenotypic biomarkers of aging

X Xia, W Chen, J McDermott, JDJ Han - F1000Research, 2017 - ncbi.nlm.nih.gov
Individuals of the same age may not age at the same rate. Quantitative biomarkers of aging
are valuable tools to measure physiological age, assess the extent of 'healthy aging', and …

Promising biomarkers of human aging: In search of a multi-omics panel to understand the aging process from a multidimensional perspective

NA Rivero-Segura, OY Bello-Chavolla… - Ageing research …, 2020 - Elsevier
The aging process has been linked to the occurrence of chronic diseases and functional
impairments, including cancer, sarcopenia, frailty, metabolic, cardiovascular, and …

[HTML][HTML] Ovulation and ovarian wound healing are impaired with advanced reproductive age

JN Mara, LT Zhou, M Larmore, B Johnson… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Aging is associated with reduced tissue remodeling efficiency and increased fibrosis,
characterized by excess collagen accumulation and altered matrix degradation. Ovulation …

The role of mTOR in ovarian neoplasms, polycystic ovary syndrome, and ovarian aging

J Liu, DC Wu, LH Qu, HQ Liao, MX Li - Clinical Anatomy, 2018 - Wiley Online Library
The mammalian target of rapamycin, mTOR, is a serine‐threonine protein kinase
downstream of the phosphatidylinositol 3‐kinase (PI3K)‐AKT axis. The pathway can …

[HTML][HTML] Differential Wnt signaling activity limits epithelial gland development to the anti-mesometrial side of the mouse uterus

J Goad, YA Ko, M Kumar, SM Syed, PS Tanwar - Developmental biology, 2017 - Elsevier
In mice, implantation always occurs towards the antimesometrial side of the uterus, while the
placenta develops at the mesometrial side. What determines this particular orientation of the …

[HTML][HTML] Extracellular matrix (ECM) activates β-catenin signaling in uterine fibroids

YA Ko, MFB Jamaluddin, M Adebayo, P Bajwa… - …, 2018 - rep.bioscientifica.com
κΩΨ¥–€™±≈‰ greater than> less than Recent studies showed that genetic aberrations in
the MED12 gene, probably through the canonical WNT/β-catenin pathway, lead to the …

[HTML][HTML] Overactive mTOR signaling leads to endometrial hyperplasia in aged women and mice

P Bajwa, S Nielsen, JM Lombard, L Rassam, P Nahar… - Oncotarget, 2017 - ncbi.nlm.nih.gov
During aging, uncontrolled epithelial cell proliferation in the uterus results in endometrial
hyperplasia and/or cancer development. The mTOR signaling pathway is one of the major …

Ageing-associated Phenotypes in Mice

K Xie, D Ehninger - Mechanisms of Ageing and Development, 2023 - Elsevier
Ageing is a continuous process in life featuring progressive damage accumulation that leads
to physiological decline, functional deterioration and ultimately death of an organism. Based …

Ectopic expression of CGG-repeats alters ovarian response to gonadotropins and leads to infertility in a murine FMR1 premutation model

KE Shelly, NR Candelaria, Z Li, EG Allen… - Human molecular …, 2021 - academic.oup.com
Women heterozygous for an expansion of CGG repeats in the 5'UTR of FMR1 risk
developing fragile X-associated primary ovarian insufficiency (FXPOI) and/or tremor and …

[HTML][HTML] The conceptual advances of carcinogenic sequence model in high‑grade serous ovarian cancer

H Kobayashi, K Iwai, E Niiro, S Morioka… - Biomedical …, 2017 - spandidos-publications.com
The present review focuses on the current status of molecular pathology in high‑grade
serous cancer (HGSC) and preneoplastic conditions. This article reviews the English …