[HTML][HTML] Piezo1 channels as force sensors in mechanical force-related chronic inflammation

H Liu, J Hu, Q Zheng, X Feng, F Zhan, X Wang… - Frontiers in …, 2022 - frontiersin.org
Mechanical damage is one of the predisposing factors of inflammation, and it runs through
the entire inflammatory pathological process. Repeated or persistent damaging mechanical …

[HTML][HTML] Inflammatory microenvironment of skin wounds

Z Wang, F Qi, H Luo, G Xu, D Wang - Frontiers in immunology, 2022 - frontiersin.org
Wound healing is a dynamic and highly regulated process that can be separated into three
overlapping and interdependent phases: inflammation, proliferation, and remodelling. This …

Piezo1‐mediated M2 macrophage mechanotransduction enhances bone formation through secretion and activation of transforming growth factor‐β1

G Cai, Y Lu, W Zhong, T Wang, Y Li, X Ruan… - Cell …, 2023 - Wiley Online Library
Macrophages are multifunctional immune system cells that are essential for the mechanical
stimulation‐induced control of metabolism. Piezo1 is a non‐selective calcium channel …

Mechanical force modulates macrophage proliferation via Piezo1‐AKT‐cyclin D1 axis

H Xu, J Guan, Z Jin, C Yin, S Wu, W Sun… - The FASEB …, 2022 - Wiley Online Library
Orthodontic tooth movement (OTM) is induced by biomechanical stimuli and facilitated by
periodontal tissue remodeling, where multiple immune cells participate in this progression. It …

[HTML][HTML] Mechanotransduction in skin inflammation

MS Shutova, WH Boehncke - Cells, 2022 - mdpi.com
In the process of mechanotransduction, the cells in the body perceive and interpret
mechanical stimuli to maintain tissue homeostasis and respond to the environmental …

[HTML][HTML] Decellularized brain extracellular matrix slice glioblastoma culture model recapitulates the interaction between cells and the extracellular matrix without a …

C Wang, Q Zhao, X Zheng, S Li, J Chen, H Zhao… - Acta Biomaterialia, 2023 - Elsevier
Decellularized extracellular matrix (dECM) is a valuable tool for generating three-
dimensional in vitro tumor models that effectively recapitulate tumor-extracellular matrix …

Piezo1 in skin wound healing and related diseases: Mechanotransduction and therapeutic implications

H Zhu, W He, P Ye, J Chen, X Wu, X Mu, Y Wu… - International …, 2023 - Elsevier
Skin wound healing is a multifaceted and intricate process involving inflammation, tissue
proliferation, and scar formation, all of which are accompanied by the continuous application …

[HTML][HTML] The role of nuclear factor kappa B (NF-κB) in the immune response against parasites

P Bąska, LJ Norbury - Pathogens, 2022 - mdpi.com
The immune system consists of various cells, organs, and processes that interact in a
sophisticated manner to defend against pathogens. Upon initial exposure to an invader …

[HTML][HTML] Serine metabolic reprogramming in tumorigenesis, tumor immunity, and clinical treatment

W Shunxi, Y Xiaoxue, S Guanbin, Y Li, J Junyu… - Advances in …, 2023 - Elsevier
Serine has been recently identified as an essential metabolite for oncogenesis, progression,
and adaptive immunity. Influenced by many physiologic or tumor environmental factors, the …

Remote activation of M2 macrophage polarization via magneto-mechanical stimulation to promote osteointegration

J Shao, J Li, L Weng, K Cheng, W Weng… - ACS Biomaterials …, 2023 - ACS Publications
Osteoimmunomodulation has been considered to play a key role in osteointegration of
orthopedic biomaterials. However, regulation of the macrophage phenotype in vivo with a …