The accurate quantification of changes in the abundance of proteins is one of the main
applications of proteomics. The maintenance of accuracy can be affected by bias and error …

Over the last decade mass spectrometry imaging (MSI) has been integrated in to many
areas of drug discovery and development. It can have significant impact in oncology drug …

Because of the heterogeneity and complexity of tumor structure, cancer drugs often cannot
effectively reach the tumor, which is one of the reasons for drug resistance and treatment …

This outlook explores how two different molecular imaging approaches might be combined
to gain insight into dynamic, subcellular metabolic processes. Specifically, we discuss how …

The behavior of an animal has substantial effects on its metabolism. Such effects, including
changes in the lipid composition of different organs, or changes in the turnover of the …

Due to their involvement in numerous biochemical pathways, neuropeptides have been the
focus of many recent research studies. Unfortunately, classic analytical methods, such as …

Matrix deposition is a critical step in obtaining reproducible and spatially representative
matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging data. To …

MALDI mass spectrometry imaging (MSI) has rapidly established itself as a powerful
biomarker discovery tool. To date, no formal investigation has assessed the center-to-center …

Mass spectrometry imaging (MSI) methods and protocols have become widely adapted to a
variety of tissues and species. However, the MSI literature contains minimal information on …

Matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI) is a
sensitive label-free technique that can be used to study a wide variety of clinical phenotypes …