Neuronal migration is a critical process in the development of the nervous system. Defects in
the migration of the neurons are associated with diseases like lissencephaly, subcortical …

Malignant tumors of the central nervous system (CNS) are among cancers with the poorest
prognosis, indicated by their association with tumors of high-level morbidity and mortality …

The role of the cell surface CD133 as a cancer stem cell marker in glioblastoma (GBM) has
been widely investigated, since it identifies cells that are able to initiate neurosphere growth …

Molecular therapies are hallmarks of “personalized” medicine, but how tumors adapt to
these agents is not well-understood. Here we show that small-molecule inhibitors of …

Background: The tumor microenvironment (TME) plays a crucial role in virtually every aspect
of tumorigenesis of glioblastoma multiforme (GBM). A dysfunctional TME promotes drug …

Glioblastoma (GBM) is a fatal tumor whose aggressiveness, heterogeneity, poor blood-brain
barrier penetration, and resistance to therapy highlight the need for new targets and clinical …

Glioblastoma (GBM) is the most aggressive and lethal brain tumor in adults. Its invasive
nature currently represents the most challenging hurdle to surgical resection. The …

The invasive and recurrent nature of glioblastoma multiforme (GBM) is linked to a small
subpopulation of cancer cells, which are self‐renewing, resistant to standard treatment …

Objective CIC gene is frequently mutated in oligodendroglial tumors with 1p19q codeletion.
However, clinical and biological impact remain poorly understood. Methods We sequenced …

Little progresses have been made in the treatment of glioblastoma (GBM), the most
aggressive and lethal among brain tumors. Recently we have demonstrated that Chloride …