Following a request from the European Commission, the Panel on Dietetic Products,
Nutrition and Allergies derived Dietary Reference Values (DRVs) for iron. These include …

During erythroid differentiation, the erythron must remodel its protein constituents so that the
mature red cell contains hemoglobin as the chief cytoplasmic protein component. For this,∼ …

Heme metabolism and erythropoiesis : Current Opinion in Hematology Heme metabolism and
erythropoiesis : Current Opinion in Hematology Log in or Register Subscribe to journalSubscribe …

Iron is an essential metal for many biologic processes in mammals. Its primary role is to bind
oxygen in the heme moiety of hemoglobin. Iron also plays a central role in the enzymatic …

The transcellular trafficking of iron from the blood into the brain interstitium depends on iron
uptake proteins in the apical membrane of brain microvascular capillary endothelial cells …

The doom and gloom of antibiotic resistance dominates public perception of this drug class.
Many believe the world has entered the post-antibiotic era. Classic and modern approaches …

During erythropoiesis, there is an enormous demand for the synthesis of the essential
cofactor of hemoglobin, heme. Heme is synthesized de novo via an eight enzyme-catalyzed …

Iron overload associated cardiac dysfunction remains a significant clinical challenge whose
underlying mechanism (s) have yet to be defined. We aim to evaluate the involvement of the …

Heme plays a critical role in catalyzing life-essential redox reactions in all cells, and its
synthesis must be tightly balanced with cellular requirements. Heme synthesis in eukaryotes …

Background Mechanisms underlying iron homeostasis dysregulation in patients with chronic
heart failure remain unsettled. In cardiomyocyte models, norepinephrine may lead to …