Diverse classes of RNA, ranging from small to long non-coding RNAs, have emerged as key
regulators of gene expression, genome stability and defence against foreign genetic …

The RNA exosome complex is the most versatile RNA-degradation machine in eukaryotes.
The exosome has a central role in several aspects of RNA biogenesis, including RNA …

Over the past decade there has been a greater understanding of genomic complexity in
eukaryotes ushered in by the immense technological advances in high-throughput …

Background Currently, resistance to tyrosine kinase inhibitors, such as gefitinib, has become
a major obstacle in improving the clinical outcome of patients with metastatic and advanced …

We have ablated the cellular RNA degradation machinery in differentiated B cells and
pluripotent embryonic stem cells (ESCs) by conditional mutagenesis of core (Exosc3) and …

Background Acquired drug resistance is a constraining factor in clinical treatment of
glioblastoma (GBM). However, the mechanisms of chemoresponsive tumors acquire …

The aim of this study was to explore the roles of the long noncoding RNA (lncRNA) urothelial
carcinoma-associated 1 (UCA1) on cisplatin resistance in ovarian cancer and the underlying …

Multiple myeloma (MM) is characterized by the decreased osteogenic potential of
mesenchymal stem cells (MSCs). Communication between cancer cells and cancer stromal …

RNA pol ymerase II (Pol II) transcribes two classes of RNAs, protein-coding and n on-protein-
c oding (ncRNA) genes. ncRNAs are also synthesized by RNA pol ymerases I and III (Pol I …

METHODS In this study, we applied an lncRNA microarray to screen the potential biomarker
for HCC. The multi-stage validation and risk score formula detection was used for validation …