Epithelial ovarian cancer (EOC) is a gynecologic malignancy with a poor prognosis due to
resistance to first-line chemotherapeutic agents. Some cancer cells are primarily dependent …

Cancer-associated fibroblasts (CAFs) are a heterogeneous cell population that plays a
crucial role in remodeling the tumor microenvironment (TME). Here, through the integrated …

Cancer is one of the leading causes of death in the world; therefore, extensive research has
been dedicated to exploring potential therapeutics, including immune checkpoint inhibitors …

Cancer-associated fibroblasts (CAFs) have distinct roles within the tumor microenvironment,
which can impact the mode and efficacy of tumor cell migration. CAFs are known to increase …

Multiple oncogenic alterations contribute to breast cancer development. Metabolic
reprogramming, deeply contributing to tumor microenvironment (TME) education, is now …

Pancreatic cancer is characterized by hidden onset, high malignancy, and early metastasis.
Although a few cases meet the surgical indications, chemotherapy remains the primary …

Obesity is a well-established risk factor for cancer, significantly impacting both cancer
incidence and mortality. However, the intricate molecular mechanisms connecting adipose …

Background Studies have shown that oxidative stress and its resistance plays important
roles in the process of tumor metastasis, and mitochondrial dysfunction caused by …

Metastasis, the spread of a tumor or cancer from the primary site of the body to a secondary
site, is a multi-step process in cancer progression, accounting for various obstacles in …

Antiangiogenic therapies, such as treatment with bevacizumab, display modest survival
benefits in ovarian cancer (OC) patients. After a transient response, the upregulation of …