Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

We are entering an era of medicine where increasingly sophisticated data will be obtained
from patients to determine proper diagnosis, predict outcomes and direct therapies. We …

Tumor microenvironment (TME), which is characterized by hypoxia, widely exists in solid
tumors. As a current research hotspot in the TME, hypoxia is expected to become a key …

Polyphenols and their derivates, a kind of natural product distributed in herb plants,
vegetables, and fruits, are the most abundant antioxidants in the human diet and have been …

Idiopathic pulmonary fibrosis (IPF) is a fatal disease with high mortality and limited effective
therapy. Herein, we reported that fluvoxamine, a selective serotonin reuptake inhibitor …

The endoplasmic reticulum (ER) is a dynamic organelle and a reliable performer for
precisely folded proteins. To maintain its function and integrity, arrays of sensory and quality …

Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer. It
has a poor response to conventional therapy and has an extremely poor 5-year survival rate …

Protein kinase R (PKR)-like endoplasmic reticulum (ER) kinase (PERK) is one of the three
major sensors in the unfolded protein response (UPR). The UPR is involved in the …

Aberrant translation, a characteristic feature of cancer, is regulated by the complex and
sophisticated RNA binding proteins (RBPs) in the canonical translation machinery. N6 …

Long noncoding RNAs (lncRNAs) play fundamental roles in cancer development; however,
the underlying mechanisms for a large proportion of lncRNAs in pancreatic ductal …