Granulin (GRN) mutations have been identified in familial frontotemporal lobar degeneration
patients with ubiquitin pathology. GRN transcript haploinsufficiency is proposed as a …

Alzheimer disease (AD) and frontotemporal dementia (FTD) are two frequent forms of
primary neurodegenerative dementias with overlapping clinical symptoms. Pathogenic …

Comorbid proteinopathies are observed in many neurodegenerative disorders including
Alzheimer's disease (AD), increase with age, and influence clinical outcomes, yet the …

Mutations in the progranulin gene (GRN), causative for Frontotemporal Lobar Degeneration
with ubiquitinimmunoreactive neuronal inclusions (FTLD-U), could also be associated with …

In 2006, mutations in the granulin gene were identified in patients with familial
Frontotemporal Lobar Degeneration. Granulin transcript haploinsufficiency has been …

Background Frontotemporal lobar degeneration (FTLD) is a heterogeneous group of
neurodegenerative diseases associated with personality changes and progressive …

Progranulin gene (PGRN) mutations cause ubiquitin-positive frontotemporal lobar
degeneration linked to chromosome 17 (FTLDU-17). The spectrum of known mutations …

In a prospective study of dementia in Flanders (Belgium), we observed a substantial fraction
of early-onset dementia patients who did not fulfill the criteria for a specific dementia …

Frontotemporal lobar degeneration (FTLD), a neurodegenerative disease primarily affecting
the frontal and temporal lobes, is one of the most common types of dementia. While the …

Our understanding of the molecular genetic basis of two common neurodegenerative
dementias, Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD), has …