Background: Progranulin (PGRN) mutations are associated with different clinical
phenotypes, including frontotemporal lobar degeneration (FTLD), corticobasal syndrome …

Abstract Background/Aims: The Alzheimer's Disease Sequencing Project (ADSP) aims to
identify novel genes influencing Alzheimer's disease (AD). Variants within genes known to …

Gene defects have been recognized as prominent factors in the etiology and pathogenesis
of neurodegeneration. Among 60 neurodegeneration-related mutations in progranulin …

Background: The prevalence of dementia in Parkinson disease (PD) increases dramatically
with advancing age, approaching 80% in patients who survive 20 years with the disease …

Based on the cerebral tans‐activation response DNA protein 43 (TDP‐43)
immunohistochemistry, frontotemporal lobar degeneration with TDP‐43 pathology (FTLD …

Cerebrospinal fluid (CSF) biomarkers (Aß1-42, total tau, P-181 tau) are currently used to
support a clinical diagnosis of Alzheimer's disease (AD). The CSF profile in frontotemporal …

Progranulin is a secreted pro-protein that has anti-inflammatory and neurotrophic effects and
is necessary for maintaining lysosomal function. Mutations in progranulin (GRN) are a major …

The discovery of new autosomal dominant and susceptibility genes for Alzheimer's disease
(AD) and frontotemporal degeneration (FTD) is revealing important new information about …

Frontotemporal lobar degeneration (FTLD) is a neurodegenerative condition that
predominantly affects behavior, social awareness, and language. It is characterized by …

Great strides have been made in the last 2 years in the field of frontotemporal lobar
degeneration (FTLD), particularly with respect to the genetics and molecular biology of FTLD …