Plasmid persistence: costs, benefits, and the plasmid paradox

AC Carroll, A Wong - Canadian journal of microbiology, 2018 - cdnsciencepub.com
Plasmids are extrachromosomal DNA elements that can be found throughout bacteria, as
well as in other domains of life. Nonetheless, the evolutionary processes underlying the …

[HTML][HTML] Chlamydia trachomatis genital infections

CM O'Connell, ME Ferone - Microbial cell, 2016 - ncbi.nlm.nih.gov
Etiology, transmission and protection: Chlamydia trachomatis is the leading cause of
bacterial sexually transmitted infection (STI) globally. However, C. trachomatis also causes …

Chlamydial plasmid-dependent pathogenicity

G Zhong - Trends in microbiology, 2017 - cell.com
Most Chlamydia species carry a 7.5 kb plasmid encoding eight open reading frames
conventionally called plasmid glycoproteins 1–8 or pGP1–8. Although the plasmid is not …

[HTML][HTML] The multiple functions of the numerous Chlamydia trachomatis secreted proteins: the tip of the iceberg

JN Bugalhão, LJ Mota - Microbial Cell, 2019 - ncbi.nlm.nih.gov
Chlamydia trachomatis serovars are obligate intracellular bacterial pathogens mainly
causing ocular and urogenital infections that affect millions of people worldwide and which …

Apoptosis inhibition by intracellular bacteria and its consequence on host immunity

SM Behar, V Briken - Current opinion in immunology, 2019 - Elsevier
Highlights•Obligate and some facultative intracellular bacterial pathogens inhibit
apoptosis.•Bacteria inhibit apoptosis by disrupting ROS generation or mitochondrial …

The emerging complexity of Chlamydia trachomatis interactions with host cells as revealed by molecular genetic approaches

RJ Bastidas, RH Valdivia - Current Opinion in Microbiology, 2023 - Elsevier
Chlamydia trachomatis (Ct) is an intracellular bacterial pathogen that relies on the activity of
secreted proteins known as effectors to promote replication and avoidance of immune …

Chlamydia trachomatis vaccines for genital infections: where are we and how far is there to go?

LM de la Maza, TL Darville, S Pal - Expert review of vaccines, 2021 - Taylor & Francis
Introduction Chlamydia trachomatis is the most common sexually transmitted bacterial
pathogen in the world. Antibiotic treatment does not prevent against reinfection and a …

[HTML][HTML] Pgp3 protein of Chlamydia trachomatis inhibits apoptosis via HO-1 upregulation mediated by PI3K/Akt activation

M Shu, J Bu, W Lei, L Chen, Z Zhou, C Lu, C Chen… - Microbial …, 2023 - Elsevier
As an obligate intracellular pathogen, Chlamydia trachomatis assumes various strategies to
inhibit host cells apoptosis, thereby providing a suitable intracellular environment to ensure …

[HTML][HTML] Plasmid-mediated virulence in Chlamydia

BJ Turman, T Darville, CM O'Connell - Frontiers in Cellular and …, 2023 - ncbi.nlm.nih.gov
Chlamydia trachomatis infection of ocular conjunctiva can lead to blindness, while infection
of the female genital tract can lead to chronic pelvic pain, ectopic pregnancy, and/or …

Immunopathogenesis of genital Chlamydia infection: insights from mouse models

J Dockterman, J Coers - Pathogens and Disease, 2021 - academic.oup.com
Chlamydiae are pathogenic intracellular bacteria that cause a wide variety of diseases
throughout the globe, affecting the eye, lung, coronary arteries and female genital tract …