Glutamate‐dependent synaptic plasticity is emerging as an important neural substrate of
addiction. These drug‐dependent neural adaptations may occur within brain systems that …

Medium-sized spiny neurons (MSNs), the predominant neuronal population of the striatum,
are an integral component of the many cortical and limbic pathways associated with reward …

Abstract l-Stepholidine (l-SPD), an alkaloid extract of the Chinese herb Stephania
intermedia, is the first compound known to exhibit mixed dopamine D1 receptor agonist/D2 …

Drug-associated cues can elicit relapse to drug seeking after abstinence. Studies with
extinction–reinstatement models implicate dopamine (DA) in the nucleus accumbens shell …

Rationale and objectives. The mechanisms underlying relapse to cocaine seeking induced
by exposure to priming cocaine injections, cues associated with cocaine self-administration …

With the advent of subtype-selective ligands and dopamine receptor knockout mice, the last
two decades have seen an explosion in research on the role of dopamine receptor subtypes …

The lateral preoptic area (LPO) is a hypothalamic region whose function has been largely
unexplored. Its direct and indirect projections to the ventral tegmental area (VTA) suggest …

Cannabinoid CB1 receptor (CB1R) signaling has been shown to play a role in the regulation
of addictive behavior. In the present study, our aim was to investigate whether the CB1R …

The mesolimbic dopamine system is considered to play a pivotal role in the locomotor
activation produced by psychostimulants and in the augmentation of this effect observed …

Currently, available therapeutics for the treatment of Parkinson's disease (PD) fail to provide
sustained and predictable relief from motor symptoms without significant risk of adverse …