Selective D1 dopamine agonists represent a potential pharmacotherapy for the treatment of
cocaine addiction. Here we report that systemic injections of the novel D1 agonist ABT‐431 …

Systemic administration of caffeine reinstates extinguished cocaine self-administration
behavior in rats, but the mechanism mediating this behavioral effect has not been …

Mechanizm prowadzący do zmiany kontrolowanego używania i nadużywania środków
uzależniających w stan niekontrolowanego uzależnienia jest przedmiotem wielu badań …

Abstract Dopamine D2 long (D2L) and D2 short (D2S) isoforms of the D2 receptor play an
important role in psychostimulant‐induced neuronal adaptations. In this study, we used …

BACKGROUND AND PURPOSE Animal models of drug‐seeking suggest that exposure to
cues associated with self‐administered drugs and drug primes might precipitate relapse via …

Dopamine has a critical role in drug reinforcement and the reinstatement of drug seeking
due to priming or exposure to drug-associated cues. In contrast, the role of dopamine in …

The aim of the present study was to investigate the effects of pretreatment with risperidone
on heroin self-administration and heroin-seeking behaviour induced by cues and heroin …

Exposure to cues previously associated with drug intake leads to relapse by activating
previously acquired memories. Based on previous findings, in which cannabinoid CB1 …

This study assessed the relationship between extracellular nucleus accumbens (NAc)
dopamine (DA) concentrations and sensitized locomotor activation following repeated …

The authors argue that drug taking is an operant behavior that is reinforced by the drug itself.
The effectiveness of a drug as a reinforcer is modulated by sensitization and habituation to …