The present study proposes a hierarchical multivariate statistical prediction model which
enables to determine the most prominent variables (physiological, biochemical and …

Rationale. Exposure to a small amount of cocaine can trigger relapse, and so an
understanding of the mechanisms underlying cocaine-seeking are important for the …

Rationale Dopamine D 2-like agonists maintain responding when substituted for cocaine in
laboratory animals. However, these effects appear to be mediated by an interaction with …

We used a rat reinstatement model to test the involvement of dopamine D 1-and D 2-like
receptors in discrete cue-induced reinstatement of food seeking. At a dose that did not alter …

Nicotinic acetylcholine receptors (nAChRs) are known to play a role in several aspects of
cocaine addiction. Recently, systemic administration of the nicotinic receptor antagonist …

Cocaine abuse leads to adaptations in brain reward circuits, where dopaminergic
neurotransmission is a fundamental component. We hypothesized that chronic cocaine self …

Rationale The dopaminergic pathways are involved in natural and drug reward related
processes. Objectives To compare the respective involvement of the dopaminergic receptors …

Rationale. Dopaminergic mechanisms are thought to be critically involved in reward-related
processes and seeking behaviour. Objective. To examine the involvement of dopamine in …

BACKGROUND: Orphanin FQ/nociceptin (OFQ/N), the endogenous ligand of the opioid
receptor–like (ORL1) receptor, blocks cocaine sensitization in rats. In this study, we tested …

Relapse is a major clinical problem and remains a major challenge in the treatment of
addictions. A goal of current research is to gain a greater understanding of the …