The amygdala is part of the brain reward circuitry that plays a role in cocaine-seeking and
abstinence in animals and cocaine craving and relapse in humans. Cocaine-seeking is …

Environmental cues associated with the previously abused drug elicit craving and relapse to
drug use in humans. Several reinstatement paradigms are used in animals to examine the …

Cocaine addiction is characterized by a persistently heightened susceptibility to drug
relapse. For this reason, the identification of medications that prevent drug relapse is a …

Chronic cocaine use reduces glutamate levels in the nucleus accumbens (NAc), and is
associated with experience‐dependent changes in (±)‐α‐amino‐3‐hydroxy‐5 …

Pharmacological activation of group II metabotropic glutamate receptors (mGluR2/3) inhibits
cocaine self‐administration and reinstatement of drug‐seeking behavior, suggesting a …

Rationale Dopamine (DA) receptor stimulation in the nucleus accumbens (NAc) plays an
important role in regulating cocaine-seeking behavior. Adenosine receptors antagonize the …

Relapse to drug taking is triggered by stimuli previously associated with consumption of
drugs of misuse (cues) and involves brain systems controlling motivated behaviour towards …

Recent studies suggest a potential role for 5-hydroxytryptamine6 (5-HT6) receptors in the
regulation of addictive behavior. In the present study, our aim was to investigate whether the …

Abstract l-DOPA is the standard treatment for Parkinson's disease (PD), but chronic
treatment typically leads to abnormal involuntary movement or dyskinesia (LID) …

It has been suggested that dopaminergic mechanisms mediate relapse to drug-seeking
behavior and both D1-and D2-like receptor mechanisms have been implicated. In contrast to …