Molecular pathogenesis and mechanisms of thyroid cancer

M Xing - Nature Reviews Cancer, 2013 - nature.com
Thyroid cancer is a common endocrine malignancy. There has been exciting progress in
understanding its molecular pathogenesis in recent years, as best exemplified by the …

The Na+/I Symporter (NIS): Mechanism and Medical Impact

C Portulano, M Paroder-Belenitsky… - Endocrine …, 2014 - academic.oup.com
Abstract The Na+/I− symporter (NIS) is the plasma membrane glycoprotein that mediates
active I− transport in the thyroid and other tissues, such as salivary glands, stomach …

BRAF Mutation in Papillary Thyroid Cancer: Pathogenic Role, Molecular Bases, and Clinical Implications

M Xing - Endocrine reviews, 2007 - academic.oup.com
In recent years, the T1799A B-type Raf kinase (BRAF) mutation in thyroid cancer has
received enthusiastic investigation, and significant progress has been made toward …

Regulation of mutant TERT by BRAF V600E/MAP kinase pathway through FOS/GABP in human cancer

R Liu, T Zhang, G Zhu, M Xing - Nature communications, 2018 - nature.com
The unique oncogene duet of coexisting BRAF V600E and TERT promoter mutations are
widely found to be a robust genetic background promoting human cancer aggressiveness …

Thyroid papillary microcarcinoma: a descriptive and meta-analysis study

E Roti, EC degli Uberti, M Bondanelli… - European Journal of …, 2008 - academic.oup.com
The authors review anatomical, clinical characteristics and prevalence of thyroid
microcarcinoma. Diagnostic procedures and risk factors of aggressiveness at diagnosis and …

Advances in targeting the Ras/Raf/MEK/Erk mitogen-activated protein kinase cascade with MEK inhibitors for cancer therapy

BB Friday, AA Adjei - Clinical cancer research, 2008 - AACR
The identification of intracellular signaling cascades important for the growth and survival of
cancer cells has led to the development of targeted cancer therapeutics aimed at blocking …

Radioactive iodine-refractory differentiated thyroid cancer and redifferentiation therapy

J Liu, Y Liu, Y Lin, J Liang - Endocrinology and Metabolism, 2019 - synapse.koreamed.org
The retained functionality of the sodium iodide symporter (NIS) expressed in differentiated
thyroid cancer (DTC) cells allows the further utilization of post-surgical radioactive iodine …

[HTML][HTML] BRAFV600E mutation in papillary thyroid microcarcinoma: a meta-analysis

F Li, G Chen, C Sheng, AM Gusdon… - Endocrine-related …, 2015 - ncbi.nlm.nih.gov
The prognostic value of the BRAFV600E mutation, resulting in poor clinical outcomes of
papillary thyroid carcinoma, has been generally confirmed. However, the association of …

BRAF mutation in papillary thyroid carcinoma: pathogenic role and clinical implications

KT Tang, CH Lee - Journal of the chinese medical association, 2010 - journals.lww.com
Papillary thyroid cancer (PTC) is the most common endocrine malignancy, accounting for 85–
90% of all thyroid cancers. Genetic alternations involving the mitogen-activated protein …

Do histological, immunohistochemical, and metabolic (radioiodine and fluorodeoxyglucose uptakes) patterns of metastatic thyroid cancer correlate with patient …

D Deandreis, A Al Ghuzlan… - Endocrine-related …, 2011 - erc.bioscientifica.com
The aim of this study is to search for relationships between histology, radioiodine (131 I)
uptake, fluorodeoxyglucose (FDG) uptake, and disease outcome in patients with metastatic …