Prognostic signatures of sphingolipids: Understanding the immune landscape and predictive role in immunotherapy response and outcomes of hepatocellular …

X Zhang, J Zhuge, J Liu, Z Xia, H Wang, Q Gao… - Frontiers in …, 2023 - frontiersin.org
Background Hepatocellular carcinoma (HCC) is a complex disease with a poor outlook for
patients in advanced stages. Immune cells play an important role in the progression of HCC …

Revealing the role of regulatory T cells in the tumor microenvironment of lung adenocarcinoma: a novel prognostic and immunotherapeutic signature

P Zhang, X Zhang, Y Cui, Z Gong, W Wang… - Frontiers in …, 2023 - frontiersin.org
Background Regulatory T cells (Tregs), are a key class of cell types in the immune system. In
the tumor microenvironment (TME), the presence of Tregs has important implications for …

Uncovering the immune microenvironment and molecular subtypes of hepatitis B-related liver cirrhosis and developing stable a diagnostic differential model by …

S Zhang, C Jiang, L Jiang, H Chen, J Huang… - Frontiers in Molecular …, 2023 - frontiersin.org
Background: Hepatitis B-related liver cirrhosis (HBV-LC) is a common clinical disease that
evolves from chronic hepatitis B (CHB). The development of cirrhosis can be suppressed by …

[HTML][HTML] Systematic analysis of the prognostic value and immunological function of LTBR in human cancer

Y Wu, S Zhao, W Guo, Y Liu, MDMR Mullor… - Aging (Albany …, 2024 - ncbi.nlm.nih.gov
Lymphotoxin beta receptor (LTBR) is a positive T cell proliferation regulator gene. It is
closely associated with the tumor immune microenvironment. However, its role in cancer …

GADD45B regulates the carcinogenesis process of chronic atrophic gastritis and the metabolic pathways of gastric cancer

W Xu, T Jiang, K Shen, D Zhao, M Zhang… - Frontiers in …, 2023 - frontiersin.org
Background Gastric cancer continues to be a significant global healthcare challenge, and its
burden remains substantial. The development of gastric cancer (GC) is closely linked to …

Efferocytosis signatures as prognostic markers for revealing immune landscape and predicting immunotherapy response in hepatocellular carcinoma

K Xu, Y Liu, H Luo, T Wang - Frontiers in Pharmacology, 2023 - frontiersin.org
Background: Hepatocellular carcinoma (HCC) is a highly lethal liver cancer with late
diagnosis; therefore, the identification of new early biomarkers could help reduce mortality …

Unveiling efferocytosis-related signatures through the integration of single-cell analysis and machine learning: a predictive framework for prognosis and …

T Liu, C Li, J Zhang, H Hu, C Li - Frontiers in Immunology, 2023 - frontiersin.org
Background Hepatocellular carcinoma (HCC) represents a prominent gastrointestinal
malignancy with a grim clinical outlook. In this regard, the discovery of novel early …

Unveiling the role of regulatory T cells in the tumor microenvironment of pancreatic cancer through single-cell transcriptomics and in vitro experiments

W Xu, W Zhang, D Zhao, Q Wang, M Zhang… - Frontiers in …, 2023 - frontiersin.org
Background In order to investigate the impact of Treg cell infiltration on the immune
response against pancreatic cancer within the tumor microenvironment (TME), and identify …

[HTML][HTML] Oxytocin alleviates liver fibrosis via hepatic macrophages

X Zhai, H Zhang, Z Xia, M Liu, G Du, Z Jiang, H Zhou… - JHEP Reports, 2024 - Elsevier
Background & Aims Previous studies demonstrated oxytocin treatment effectiveness in
reducing mortality and reversing liver fibrosis in mice. However, the underlying mechanism …

[HTML][HTML] Identification of mitochondrial-related signature and molecular subtype for the prognosis of osteosarcoma

X Zhao, J Zhang, J Liu, Q Chen, C Cai, X Miao… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Mitochondria play a vital role in osteosarcoma. Therefore, the purpose of this study was to
investigate the potential role of mitochondrial-related genes (MRGs) in osteosarcoma …