Ideal surgical treatment for anal fistula should aim to eradicate sepsis and promote healing
of the tract, whilst preserving the sphincters and the mechanism of continence. For the …

It is over 10 years since the first ACPGBI Position Statement on the management of anal
fistula was published in 2007. This second edition is the result of scrutiny of the literature …

Background The mostly widely studied biomaterials for the sphincter sparing treatment of
anal fistulas are fibrin glue and the anal fistula plug (AFP). However their overall mean …

Extracellular vesicles (EVs) are increasingly envisioned as the next generation of biological
pro-regenerative nanotherapeutic agents, as has already been demonstrated for heart …

Background Optimal treatment for high/complex anal fistulas is uncertain. We have studied
one surgeon's results over a ten-year period, concentrating on high fistulas. Methods …

Extracellular vesicles (EVs), especially from stem/stromal cells (SCs), represent a cell-free
alternative in regenerative medicine holding promises to promote tissue healing while …

Aim Permacol™ collagen paste (Permacol paste) is a new option for the treatment of
anorectal fistula. It functions by filling the fistula tract with an acellular crosslinked porcine …

Aim Fibrin glue and porcine intestinal submucosa are used in novel sphincter‐preserving
techniques to heal anal fistulae. However, their success is highly variable and decreases …

Fistula arising from the glands of the anal crypts is the most common form of anoperineal
sepsis. It is characterized by a primary internal orifice in the anal canal, a fistulous tract, and …

Background The aim of the present study was to assess a novel autologous cartilage plug
technique used to treat anal fistula in ten patients. Methods All ten patients had undergone …