Obesity, diabetes mellitus, hypertension and cardiovascular disease are risk factors for
chronic kidney disease (CKD) and kidney failure. Chronic, low-grade inflammation is …

Lipids encompass a wide variety of molecules such as fatty acids, sterols, phospholipids,
and triglycerides. These molecules represent a highly efficient energy resource and can act …

Obesity is a major public health problem worldwide, and it is associated with an increased
risk of developing type 2 diabetes. It is now commonly accepted that chronic inflammation …

Obesity is becoming a major health concern in Western society, and medical conditions
associated with obesity are grouped in the metabolic syndrome. Overnutrition activates …

A primary cause of disease progression in type 2 diabetes (T2D) is β cell dysfunction due to
inflammatory stress and insulin resistance. However, preventing β cell exhaustion under …

Type 2 diabetes mellitus (T2DM), accounting for 90–95% cases of diabetes, is characterized
by chronic inflammation. The mechanisms that control inflammation activation in T2DM are …

The inability of pancreatic β-cells to make sufficient insulin to control blood sugar is a central
feature of the aetiology of most forms of diabetes. In this review we focus on the deleterious …

Type 2 diabetes mellitus, a common metabolic and endocrine disorder worldwide, causes
severe health and economic problems. At present, pharmacotherapy involving synthetic …

Objectives Even with great advances in modern medicine and therapeutic agent
development, the search for effective antidiabetic drugs remains challenging. Coumarins are …

Inflammatory damage contributes to β cell failure in type 1 and 2 diabetes (T1D and T2D,
respectively). Mitochondria are damaged by inflammatory signaling in β cells, resulting in …