Plant lectins: occurrence, biochemistry, functions and applications

H Rüdiger, HJ Gabius - Glycoconjugate journal, 2001 - Springer
Growing insights into the many roles of glycoconjugates in biorecognition as ligands for
lectins indicates a need to compare plant and animal lectins. Furthermore, the popularity of …

Chemical biology of the sugar code

HJ Gabius, HC Siebert, S André… - …, 2004 - Wiley Online Library
A high‐density coding system is essential to allow cells to communicate efficiently and
swiftly through complex surface interactions. All the structural requirements for forming a …

Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunction

UC Sharma, S Pokharel, TJ Van Brakel, JH Van Berlo… - Circulation, 2004 - Am Heart Assoc
Background—Inflammatory mechanisms have been proposed to be important in heart
failure (HF), and cytokines have been implicated to add to the progression of HF. However, it …

The sugar code: functional lectinomics

HJ Gabius, S André, H Kaltner, HC Siebert - Biochimica et Biophysica Acta …, 2002 - Elsevier
Analysis of the genome and proteome assumes the focus of attention in efforts to relate
biochemical coding with cell functionality. Among other chores in energy metabolism, the …

Drug targeting to the colon with lectins and neoglycoconjugates

T Minko - Advanced drug delivery reviews, 2004 - Elsevier
Targeting of drugs to specific sites of action provides several advantages over non-targeted
drugs. These include the prevention of side effects of drugs on healthy tissues and …

Magnetic glyco-nanoparticles: a tool to detect, differentiate, and unlock the glyco-codes of cancer via magnetic resonance imaging

K El-Boubbou, DC Zhu, C Vasileiou… - Journal of the …, 2010 - ACS Publications
Within cancer, there is a large wealth of diversity, complexity, and information that nature has
engineered rendering it challenging to identify reliable detection methods. Therefore, the …

[HTML][HTML] Negative regulation of neuroblastoma cell growth by carbohydrate-dependent surface binding of galectin-1 and functional divergence from galectin-3

J Kopitz, C von Reitzenstein, S André, H Kaltner… - Journal of Biological …, 2001 - ASBMB
The cell density-dependent growth inhibition of human SK-N-MC neuroblastoma cells is
initiated by increased ganglioside sialidase activity leading to elevated cell surface …

Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures

H Lahm, S André, A Hoeflich, JR Fischer… - Journal of cancer …, 2001 - Springer
Purpose: Knowledge about galectin expression by human tumor cells is mainly restricted to
galectins-1 and-3. This study was conducted to define the gene expression pattern of all …

Galectins are differentially expressed in supratentorial pilocytic astrocytomas, astrocytomas, anaplastic astrocytomas and glioblastomas, and significantly modulate …

I Camby, N Belot, S Rorive, F Lefranc… - Brain …, 2001 - Wiley Online Library
Galectins, a family of mammalian lectins with specificity to β‐galactosides, are involved in
growth‐regulatory mechanisms and cell adhesion. A relationship is assumed to exist …

Refined prognostic evaluation in colon carcinoma using immunohistochemical galectin fingerprinting

N Nagy, H Legendre, O Engels, S André… - … Journal of the …, 2003 - Wiley Online Library
BACKGROUND Knowledge of the expression of the galectins in human colon carcinomas is
mainly restricted to galectin‐3 and, to a lesser extent, galectin‐1. The current study analyzed …