Galectin-3–an emerging prognostic indicator in advanced head and neck carcinoma

J Plzák, J Betka, K Smetana Jr, M Chovanec… - European Journal of …, 2004 - Elsevier
Galectin-3, is a multifunctional effector. It is the only chimera-type member of the galectin
family of endogenous lectins, which share specificity with β-galactosides and have a jelly …

Human galectin-2: expression profiling by RT-PCR/immunohistochemistry and its introduction as a histochemical tool for ligand localization

I Saal, N Nagy, M Lensch, M Lohr… - Histology and …, 2005 - digitum.um.es
Sugar-encoded information of glycoconjugates is translated into cellular responses by
endogenous lectins. Galectins stand out against other lectin families due to their wide range …

[HTML][HTML] Detection of ligand-and solvent-induced shape alterations of cell-growth-regulatory human lectin galectin-1 in solution by small angle neutron and X-ray …

L He, S André, HC Siebert, H Helmholz, B Niemeyer… - Biophysical journal, 2003 - cell.com
The bioactivity of galectin-1 in cell growth regulation and adhesion prompted us to answer
the questions whether ligand presence and a shift to an aprotic solvent typical for bioaffinity …

New aspects of galectin functionality in nuclei of cultured bone marrow stromal and epidermal cells: biotinylated galectins as tool to detect specific binding sites

T Purkrábková, K Smetana Jr, B Dvořánková… - Biology of the …, 2003 - Wiley Online Library
Nuclear presence of galectins suggests a role of these endogenous lectins in the regulation
of transcription, pre‐mRNA splicing and transport processes. Therefore, detection and …

Glycoprotein targeting and other applications of lectins in biotechnology

A Naeem, M Saleemuddin… - Current Protein and …, 2007 - ingentaconnect.com
Glycoconjugates comprise a variety of structures, include glycoproteins and glycolipids and
are found on the surfaces of animal and plant cells, as well as on the surface of …

Discovery of galectin ligands in fully randomized combinatorial one-bead-one-compound (glyco) peptide libraries

S André, CEP Maljaars, KM Halkes, HJ Gabius… - Bioorganic & medicinal …, 2007 - Elsevier
The involvement of human lectins (galectins) in disease progression accounts for the
interest to design potent inhibitors. Three fully randomized hexa (glyco) peptide libraries …

Activity–structure correlations in divergent lectin evolution: fine specificity of chicken galectin CG-14 and computational analysis of flexible ligand docking for CG-14 …

AM Wu, T Singh, JH Liu, M Krzeminski… - …, 2007 - academic.oup.com
Gene duplication and sequence divergence are driving forces toward establishing protein
families. To examine how sequence changes affect carbohydrate specificity, the two closely …

[PDF][PDF] Immunohistochemical Fingerprinting of the Network of Seven Adhe sion/Growth-Regulatory Lectins in Human Skin and De-tection of Distinct Tumour …

Z Čada, K Smetana Jr, L Lacina, Z Plzáková… - Folia Biologica …, 2009 - radio.lf1.cuni.cz
Glycans of natural glycoconjugates are considered as a source of biological information
relevant to cell adhesion or growth. Sugar-based messages are decoded and translated into …

[PDF][PDF] Glycophenotype of psoriatic skin

L Lacina, Z Plzáková, K Smetana, J Stork… - FOLIA BIOLOGICA …, 2006 - ortbul.lf1.cuni.cz
Psoriasis is considered an auto-immune disease with consequential keratinocyte
hyperproliferation resulting in specific architecture of psoriatic skin. This process is …

Lectinomics I. Relevance of exogenous plant lectins in biomedical diagnostics

D Mislovičová, P Gemeiner, A Kozarova, T Kožár - Biologia, 2009 - degruyter.com
This review focuses on utilization of plant lectins as medical diagnostic reagents and tools.
The lectin-related diagnostic is aimed at detection of several diseases connected to …