[HTML][HTML] Molecular regulation of toll-like receptors in asthma and COPD
Asthma and chronic obstructive pulmonary disease (COPD) have both been historically
associated with significant morbidity and financial burden. These diseases can be induced …
associated with significant morbidity and financial burden. These diseases can be induced …
Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish
Neutrophil lifespan and function are regulated by hypoxia via components of the hypoxia
inducible factor (HIF)/von Hippel Lindau/hydroxylase pathway, including specific roles for …
inducible factor (HIF)/von Hippel Lindau/hydroxylase pathway, including specific roles for …
Targeting neutrophils using novel drug delivery systems in chronic respiratory diseases
DK Chellappan, LW Yee, KY Xuan… - Drug development …, 2020 - Wiley Online Library
Neutrophils are essential effector cells of immune system for clearing the extracellular
pathogens during inflammation and immune reactions. Neutrophils play a major role in …
pathogens during inflammation and immune reactions. Neutrophils play a major role in …
Neutrophil granule proteins tune monocytic cell function
Polymorphonuclear leukocytes (PMNs) release the contents of granules during their
migration to inflammatory sites. On liberation from the first leukocyte to enter injured tissue …
migration to inflammatory sites. On liberation from the first leukocyte to enter injured tissue …
High mobility group protein-1 inhibits phagocytosis of apoptotic neutrophils through binding to phosphatidylserine
Phagocytosis of apoptotic cells, also called efferocytosis, is an essential feature of immune
responses and critical to resolution of inflammation. Impaired efferocytosis is associated with …
responses and critical to resolution of inflammation. Impaired efferocytosis is associated with …
SB‐656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone‐induced airway inflammation in humans
AL Lazaar, LE Sweeney, AJ MacDonald… - British journal of …, 2011 - Wiley Online Library
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Receptor antagonists that block the
binding of chemokines such as CXCL8 (IL‐8) are effective in animals models of neutrophil …
binding of chemokines such as CXCL8 (IL‐8) are effective in animals models of neutrophil …
[HTML][HTML] A fragile balance: does neutrophil extracellular trap formation drive pulmonary disease progression?
H Block, A Zarbock - Cells, 2021 - mdpi.com
Neutrophils act as the first line of defense during infection and inflammation. Once activated,
they are able to fulfil numerous tasks to fight inflammatory insults while keeping a balanced …
they are able to fulfil numerous tasks to fight inflammatory insults while keeping a balanced …
[HTML][HTML] Smoking status and tumor necrosis factor-alpha mediated systemic inflammation in COPD patients
Background Smoking cause airway and systemic inflammation and COPD patients present
low grade inflammation in peripheral blood. However, data on the influence of smoking itself …
low grade inflammation in peripheral blood. However, data on the influence of smoking itself …
Measuring chlorine bleach in biology and medicine
AJ Kettle, AM Albrett, AL Chapman, N Dickerhof… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Background Chlorine bleach, or hypochlorous acid, is the most reactive two-electron oxidant
produced in appreciable amounts in our bodies. Neutrophils are the main source of …
produced in appreciable amounts in our bodies. Neutrophils are the main source of …
Neutrophilic inflammation in the pathogenesis of chronic obstructive pulmonary disease
Current paradigms of chronic obstructive pulmonary disease (COPD) treatment suggest
stratifying patients by their symptoms, utilising three main drug classes, but it is unclear if this …
stratifying patients by their symptoms, utilising three main drug classes, but it is unclear if this …